Home Chemistry Organic Building Blocks Trifluoromethyls 2-(Trifluoromethyl)Benzoic Acid
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —CF3,—COOH).
Friedel-Crafts Acylation/Alkylation: The (trifluoromethyl)benzene can undergo Friedel-Crafts acylation or alkylation reactions, in which an acyl or alkyl group is added to the benzene ring. These reactions are catalyzed by Lewis acids and result in the formation of new carbon-carbon bonds.
Friedel-Crafts Acylation: Benzoic acid can undergo Friedel-Crafts acylation reactions with aromatic compounds in the presence of a Lewis acid catalyst such as aluminum chloride (AlCl3). This reaction results in the introduction of an acyl group (RCO-) onto the aromatic ring.
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3-Chloro-2-fluoro-6-(trifluoromethyl)benzoic acid
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4-Borono-2-(trifluoromethyl)benzoic acid
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4-Cyano-2-(trifluoromethyl)benzoic acid
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4-Methoxy-2-(trifluoromethyl)benzoic acid
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5-(((tert-Butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoic acid
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2,5-Bis(trifluoromethyl)terephthalic acid
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5-Amino-2-(trifluoromethyl)benzoic acid
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2-Methyl-6-(trifluoromethyl)benzoic acid
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