Home Chemistry Heterocyclic Building Blocks Pyridines 2-Bromo-3-Chloropyridine
Nucleophilic Substitution: The bromine atom can be replaced by a nucleophile (e.g., hydroxide ion, amine) leading to the formation of a new compound with a substituted pyridine ring.
Electrophilic Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile substitutes for one of the hydrogen atoms on the ring. This could occur at the positions ortho, meta, or para to the chlorine atom.
Cross-Coupling Reactions: 2-Bromo-3-chloropyridine can participate in various cross-coupling reactions, such as Suzuki coupling or Heck coupling, where it reacts with suitable coupling partners (e.g., boronic acids, alkenes) under appropriate conditions to form biaryl or aryl-alkene products.
Metalation: The pyridine ring can be deprotonated using strong bases like butyllithium or Grignard reagents to form metalated intermediates, which can further react with electrophiles or undergo transformations like metal-halogen exchange.
Reductive Reactions: The bromine and chlorine atoms can be substituted with hydrogen atoms using reducing agents like lithium aluminum hydride (LiAlH4) or palladium-catalyzed hydrogenation, resulting in the formation of corresponding halogen-free pyridine derivatives.
Functional Group Transformations: Various functional group transformations such as halogenation, oxidation, and reduction reactions can be carried out on 2-bromo-3-chloropyridine to introduce or modify other functional groups on the molecule.
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2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
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