Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-3-Iodopyridine
Substitution Reactions: The halogens (chlorine and iodine) in the molecule can be substituted by other nucleophiles. For instance, they can be replaced by another nucleophilic group such as hydroxyl (-OH), amino (-NH2), or alkoxide (-OR). These reactions can be catalyzed by a base or a transition metal catalyst.
Cross-Coupling Reactions: The compound can undergo cross-coupling reactions, such as Suzuki coupling, Stille coupling, or Heck reaction, where the halogen atoms are replaced by a carbon-based group. This can be useful for synthesizing more complex organic molecules.
Metal-Halogen Exchange: The halogen atoms can undergo exchange reactions with certain metals, such as lithium or magnesium, leading to the formation of organometallic compounds. These compounds are versatile intermediates in organic synthesis.
Redox Reactions: The compound can undergo redox reactions, where the oxidation states of the chlorine and iodine atoms change. For example, the iodine atom can be reduced to iodide ion while the chlorine atom is oxidized to chloride ion, or vice versa.
Elimination Reactions: Under certain conditions, such as high temperature or the presence of a strong base, elimination reactions can occur where a molecule of HCl or HI is removed, leading to the formation of a double bond in the pyridine ring.
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5-(Bromomethyl)-2-chloro-3-iodopyridine
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2-Chloro-3-iodo-5-(trifluoromethyl)pyridine
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