Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-3-Methoxypyridine
Nucleophilic substitution: The chlorine atom (-Cl) can be replaced by a nucleophile, leading to the formation of substituted pyridine derivatives.
Electrophilic aromatic substitution: The pyridine ring can undergo substitution reactions with electrophilic reagents, such as acids or acyl chlorides, resulting in the introduction of new substituents onto the ring.
Metalation: The pyridine ring can be metalated by treatment with strong bases or metal-amide bases, leading to the formation of metal complexes.
Cross-coupling reactions: 2-chloro-3-methoxypyridine can participate in cross-coupling reactions with various coupling partners, such as organometallic reagents (e.g., Grignard reagents) or transition metal catalysts, leading to the formation of biaryl compounds.
Reductive reactions: The chloro group can undergo reduction to form the corresponding methyl group or other reduced products under appropriate conditions.
Oxidation reactions: The methoxy group can be oxidized to a variety of functional groups, such as aldehydes, ketones, or carboxylic acids, depending on the reaction conditions.
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2-Chloro-3-methoxy-5-(trifluoromethyl)pyridine
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(6-Chloro-5-methoxy-pyridin-2-yl)-methanol
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(6-Chloro-5-methoxypyridin-3-yl)boronic acid
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1-(6-Chloro-5-methoxypyridin-3-yl)ethanone
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