Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloroisonicotinic Acid
Substitution reactions: The chlorine atom can undergo substitution reactions with various nucleophiles, such as amines or hydroxide ions, leading to the formation of substituted products.
Esterification: The carboxylic acid group can undergo esterification reactions with alcohols in the presence of acid catalysts to form esters .
Amidation: The carboxylic acid group can react with amines to form amides.
Decarboxylation: Under certain conditions, such as heating, 2-chloroisonicotinic acid may undergo decarboxylation, resulting in the loss of carbon dioxide and formation of the corresponding substituted pyridine compound.
Coupling reactions: It can participate in coupling reactions, such as the Ullmann reaction or Suzuki reaction, with suitable coupling partners to form biaryl compounds.
Oxidation: It can undergo oxidation reactions under appropriate conditions, converting the chloro group to other functional groups or forming new bonds.
Reduction: It can undergo reduction reactions, converting the carboxylic acid group to an alcohol or aldehyde, or reducing the chloro group to a primary amine.
Grignard reaction: It can react with Grignard reagents to form substituted products.
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2-Chloro-3-methyl-4-pyridinecarboxylic Acid
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2-Chloro-6-(trifluoromethyl)isonicotinic acid
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2-Chloro-6-methoxypyridine-4-carboxylic Acid
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2-Chloro-5-(trifluoromethoxy)isonicotinic acid
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2-Chloro-5-(trifluoromethyl)pyridine-4-carboxylic acid
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