Home Chemistry Heterocyclic Building Blocks Pyridines 3-Nitropyridin-4-Amine
Reduction: The nitro group (-NO2) can be reduced to an amino group (-NH2) under suitable conditions, typically using reducing agents such as hydrogen gas (H2) over a metal catalyst (e.g., palladium on carbon), or using metal hydrides like sodium borohydride (NaBH4) or iron and hydrochloric acid (Fe/HCl).
Substitution Reactions: The amino group (-NH2) can undergo substitution reactions, where another group replaces the amino group. For example, acylation reactions with acyl chlorides or acid anhydrides, or alkylation reactions with alkyl halides or sulfonates.
Nucleophilic Aromatic Substitution: The amino group (-NH2) can act as a nucleophile in aromatic substitution reactions. Under suitable conditions, it can displace a leaving group from the aromatic ring, leading to substitution products.
Diazotization: The amino group (-NH2) can undergo diazotization reactions, where it is converted into a diazonium salt using nitrous acid (HNO2) in acidic conditions. Diazonium salts are versatile intermediates in organic synthesis.
Coupling Reactions: Diazonium salts derived from the amino group (-NH2) can undergo coupling reactions with aromatic compounds, phenols, or other nucleophiles to form azo compounds, which are important dyes and pigments.
Oxidation: The amine group can be oxidized under certain conditions to form nitro compounds or other oxidation products.
Condensation Reactions: The amino group can participate in condensation reactions, forming imines or Schiff bases with carbonyl compounds.
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