Home Chemistry Heterocyclic Building Blocks Pyridines 5-Chloropicolinic Acid
Substitution Reactions: The chlorine atom in 5-chloropicolinic acid can undergo substitution reactions with various nucleophiles to form different derivatives of picolinic acid.
Esterification: The carboxylic acid group in 5-chloropicolinic acid can undergo esterification reactions with alcohols in the presence of acid catalysts to form esters.
Acylation: The carboxylic acid group can also undergo acylation reactions with acylating agents, such as acyl chlorides or acid anhydrides, to form amides.
Decarboxylation: Under certain conditions, such as heating, 5-chloropicolinic acid may undergo decarboxylation to form 5-chloro-2-pyridone.
Metal Complex Formation: The nitrogen atom in the pyridine ring can coordinate with metal ions to form metal complexes, which can have various applications in catalysis or coordination chemistry.
Oxidation/Reduction Reactions: The hydroxyl group in 5-chloropicolinic acid can undergo oxidation to form a ketone or reduction to form an alcohol.
Cyclization Reactions: Depending on the reaction conditions and reagents, cyclization reactions involving the pyridine ring can occur, leading to the formation of various heterocyclic compounds.
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5-Chloro-4-(difluoromethoxy)picolinicacid
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5-Chloro-3-methylpyridine-2-carboxylic acid
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