Home Chemistry Organic Building Blocks Bromides Methyl 2-(2-Bromophenyl)Acetate
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Br,—CH2COOCH3).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Ester Hydrolysis: Methyl 2-phenylacetate can undergo hydrolysis in the presence of an acid or base to form the corresponding 【carboxylic acid|https://www.ambeed.com/carboxylic-acids.html】 (2-phenylacetic acid) and methanol. The reaction mechanism differs depending on whether acid or base is used.
Acid-Catalyzed Hydrolysis: CH3-CO-CH2-C6H5 + H2O (in the presence of acid) → CH3-COOH + C6H5OH
Base-Catalyzed Hydrolysis: CH3-CO-CH2-C6H5 + OH- (in the presence of base) → CH3-COO- + CH2-C6H5OH CH3-COO- + H2O → CH3-COOH
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Methyl 2-(2-bromo-3-methylphenyl)acetate
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Methyl 2-(2-bromo-6-fluorophenyl)acetate
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Methyl 2-(2-bromo-4-chlorophenyl)acetate
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Methyl 2-(2-bromo-3-chlorophenyl)acetate
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