Events & News

Events & News

Decoding Prostate Cancer: The Molecular Blueprint and Targeted Treatment Landscape (Part I)

Prostate cancer (PC) is an androgen-driven, male-specific malignancy. According to The Lancet [1], it ranks as the second most common cancer in men globally, accounting for 15% of all male cancers. In the United States, PC is the most prevalent cancer among men.

2025-09-09

Pure-blue single-layer organic light-emitting diodes based on trap-free hyperfluorescence

OLED technology has already matured for high-end displays, blue OLEDs still lag behind their green and red counterparts. Blue fluorescent emitters offer good stability but suffer from limited efficiency because only singlet excitons are harvested. Blue phosphorescent emitters achieve higher efficiency via triplet harvesting, yet their operational stability remains low. Over the past decade, thermally activated delayed fluorescence (TADF) has emerged as a promising alternative, but blue TADF devices likewise exhibit insufficient stability and intrinsically broad spectra that compromise colour purity. To improve colour purity, researchers have proposed introducing a small amount of narrow-band fluorescent emitter into the TADF system and realizing hyperfluorescence through energy transfer. However, this approach risks additional energy losses, and current efforts focus primarily on suppressing Dexter energy transfer—namely, the non-radiative transfer of TADF triplet excitons to the fluorescent emitter. The main countermeasures are (1) employing the fluorescent emitter at an extremely low concentration (1 %–2 %) to reduce short-range Dexter transfer, and (2) adopting TADF emitters with a high reverse intersystem crossing (RISC) rate to decrease the triplet-exciton density.

2025-09-03

Chemoselective synthesis of 1,3,4-thiadiazoles from acyl hydrazines and nitroalkanes using elemental sulfur

In medicinal chemistry, the 1,3,4-thiadiazole ring is a privileged pharmacophore found in numerous therapeutic agents, including the antibacterial cefazedone, the antipsychotic candidate MK-8189, and the anti-NASH drug BI-3231 (Fig. 1a). Traditional syntheses, however, rely on highly toxic P₂S₅ or Lawesson’s reagent under harsh anhydrous conditions and exhibit limited substrate scope, severely restricting their application to complex molecules. Developing a mild, modular route to these motifs has therefore become a critical unmet need.

2025-08-26

Enantioconvergent benzylic C(sp3)‒N coupling with a copper-substituted nonheme enzyme

The construction of C(sp3)‒N bonds represents an indispensable process in organic synthesis because of the prevalence of nitrogen-containing molecules in bioactive compounds, pharmaceuticals, and functional materials. Among the various strategies for C(sp3)–N bond formation, copper-catalyzed radical C(sp3)–N coupling has emerged as a leading approach over the past decade (Figure 1A). In parallel with these advances in synthetic chemistry, biocatalytic methods for constructing C(sp3)‒N bonds have represented another rap idly growing research area in the past 20 years (Figure 1B). In this context, incorporating copper-catalyzed radical C(sp3)‒N coupling into biocatalysis is appealing because it would merge the genetic tunability and selectivity of enzymes with the broad reaction scope of copper radical catalysis.

2025-08-25

Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation

The arrival of mRNA vaccines has marked a watershed moment for cancer therapy and infectious-disease prevention. Lipid nanoparticles (LNPs), the core delivery vehicles for these vaccines, demonstrated revolutionary value during COVID-19 vaccine development. Yet conventional polyethylene-glycol-conjugated LNPs (PEG-LNPs) still exhibit pronounced hepatic accumulation after intramuscular injection, incurring risks of hepatotoxicity and heightened immunogenicity that hinder further advances in oncology and prophylaxis. Optimizing the delivery system has therefore become the central challenge for improving vaccine safety and efficacy.

2025-08-21

Breast Cancer Research: Rapid Progress and Innovation

The field of breast cancer research is advancing rapidly, with increasingly refined subtype classifications, complex signalling pathways, and innovative treatment approaches. Whether considering endocrine therapy for luminal breast cancer, targeted therapies for HER2-overexpressing subtypes, or chemotherapy explorations for triple-negative breast cancer, these developments continuously bring new hope to patients. The following provides cutting-edge information on breast cancer, offering in-depth knowledge to support advances in precision medicine.

2025-08-13

Diversity-oriented photobiocatalytic synthesis via stereoselective three-component radical coupling

In recent years, the field of synthetic chemistry is undergoing a transformation centered on diversity-oriented synthesis (DOS). As a powerful strategy, DOS addresses both chemical and biological challenges by generating functional compound libraries that exhibit excellent skeletal, functional group, and stereochemical diversity. Among the various approaches, multicomponent reactions are particularly attractive because they rapidly assemble molecular complexity from readily available building blocks in a single operation. Enzymes can impose outstanding stereocontrol over challenging chemical reactions; however, beyond multi-domain mega-synthases such as non-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), employing a single-domain enzyme or a set of closely related enzyme mutants for diversity-oriented synthesis remains a formidable challenge.

2025-08-12

Selective Iridium-Catalyzed Reductive Amination Inside Living Cells

This article is about a novel biocompatible method that uses iridium-catalyzed reductive amination reactions to selectively synthesize primary amines (1°), secondary amines (2°), and tertiary amines (3°) in living cells. This method utilizes 4-(1-aminoethyl)phenol as a self-immolative nitrogen donor, combined with an electron-deficient iridium catalyst, to achieve the efficient and selective synthesis of various amine compounds from a range of aldehydes and nitrogen precursors under physiological conditions. The article provides a detailed description of the development, optimization, mechanism exploration, and application of this method in living cells, offering a new tool for studying and manipulating living systems.

2025-08-11

New Perspectives in Cancer and Immunotherapy Research: The Potential of Metabolic Pathways in Oncology

Metabolic alterations in cancer cells represent one of the hallmarks of malignancy. However, when attempting to treat cancer through metabolic modulation, we must simultaneously consider the metabolic pathways of immune cells. As our understanding of immunometabolism deepens, it becomes evident that by regulating metabolic pathways, we can not only directly inhibit tumor cell growth but also enhance immune cell function, thereby achieving more effective anti-cancer responses.

2025-08-08

Breakthrough in Mitsunobu: A Bench-Stable, Universal Activator for Stereospecific SN2 of Alcohols

BEHT triflate (A2871694, AmBeed) is a thermally stable, non-explosive, and cost-effective reagent for the stereospecific conversion of alcohols into amines. Acting as a Mitsunobu-type substitute, it mediates direct nucleophilic substitution of alcohols with amines under mild conditions, typically affording excellent yields and enantiomeric purity.

2025-08-08

1 2 3 4