Home Chemistry Heterocyclic Building Blocks Pyridines Nicotinic Acid
Vasodilation: Nicotinic acid can cause the blood vessels to dilate, leading to a temporary flushing sensation and reddening of the skin. This flushing reaction is a well-known side effect of high-dose nicotinic acid supplementation.
Lowering of cholesterol: Nicotinic acid has been shown to reduce levels of LDL cholesterol (often referred to as "bad" cholesterol) and triglycerides while increasing levels of HDL cholesterol (often referred to as "good" cholesterol). This effect is beneficial for cardiovascular health.
Gastrointestinal disturbances: Some individuals may experience gastrointestinal discomfort, such as nausea, vomiting, diarrhea, or stomach upset, when taking nicotinic acid supplements, especially in high doses or on an empty stomach.
Liver enzyme elevation: In rare cases, high doses of nicotinic acid can lead to elevated levels of liver enzymes in the blood, indicating potential liver toxicity. Monitoring liver function is important when using nicotinic acid supplements, especially at high doses.
Glucose metabolism: Nicotinic acid may affect glucose metabolism, potentially leading to changes in blood sugar levels. This effect is particularly relevant for individuals with diabetes or insulin resistance.
Allergic reactions: Although rare, some individuals may experience allergic reactions to nicotinic acid supplements, which can manifest as skin rashes, itching, or difficulty breathing.
Other effects: Nicotinic acid may also interact with certain medications or medical conditions. For example, it can enhance the effects of drugs used to lower blood sugar levels or blood pressure. Additionally, individuals with certain medical conditions, such as gout or liver disease, may need to exercise caution when using nicotinic acid supplements.
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4-Hydroxy-6-(trifluoromethyl)nicotinic acid
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5-Chloro-2-(trifluoromethyl)nicotinic acid
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2-Methyl-6-(trifluoromethyl)nicotinic acid
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6-(((tert-Butoxycarbonyl)amino)methyl)nicotinic acid
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6-(2-(tert-Butoxycarbonyl)hydrazinyl)nicotinic acid
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