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CAS No. :	1268524-70-4
Formula :	C₂₃H₂₅ClN₄O₂S
M.W :	456.99
SMILES Code :	O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
MDL No. :	MFCD22683748
InChI Key :	DNVXATUJJDPFDM-KRWDZBQOSA-N
Pubchem ID :	46907787

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

ARP-1	0.5 μM	72 h	JQ1 upregulated the expression of MICA in ARP-1 cells.	J Hematol Oncol. 2016 Dec 1;9(1):134.
JJN3	0.5 μM	72 h	JQ1 upregulated the expression of MICA in JJN3 cells.	J Hematol Oncol. 2016 Dec 1;9(1):134.
U266	0.5 μM	72 h	JQ1 upregulated the expression of MICA in U266 cells.	J Hematol Oncol. 2016 Dec 1;9(1):134.
RPMI-8226	0.5 μM	72 h	JQ1 upregulated the expression of MICA in RPMI-8226 cells.	J Hematol Oncol. 2016 Dec 1;9(1):134.
Adult rat ventricular fibroblasts (ARVFs)	10μM to 5nM	72 h	JQ1 inhibited TGF-β1-stimulated α-SMA signal with an IC50 of 94nM.	Circ Res. 2019 Sep 13;125(7):662-677.
Adult rat ventricular fibroblasts (ARVFs)	500nM	72 h	JQ1 significantly reduced basal and TGF-β-mediated collagen gel contraction and profoundly reduced α-SMA protein expression.	Circ Res. 2019 Sep 13;125(7):662-677.
KP-4 cells	500 nM	9 h	JQ1 increased LC3II levels, indicating that JQ1 activates autophagy by inhibiting BRD4	Mol Cell. 2017 May 18;66(4):517-532.e9.
NMC 797 cells	500 nM	48 h	JQ1 induces differentiation in NMC cells, characterized by changes in cell morphology and increased keratin expression	Nature. 2010 Dec 23;468(7327):1067-73.
U2OS cells	500 nM		JQ1 competitively binds to BRD4, leading to its displacement from nuclear chromatin as demonstrated by FRAP experiments	Nature. 2010 Dec 23;468(7327):1067-73.
SKO-007(J3)	0.5 μM	72 h	JQ1 upregulated the expression of MICA in SKO-007(J3) cells, enhancing their sensitivity to NK cell-mediated cytotoxicity.	J Hematol Oncol. 2016 Dec 1;9(1):134.
cortical neurons	250 nM	10 min	JQ1 pretreatment blocked the rapid induction of Arc, Fos, and Nr4a1 after TTX withdrawal	Nat Neurosci. 2015 Oct;18(10):1464-73.
cortical neurons	250 nM	10 min	JQ1 pretreatment blocked the BDNF-induced increase in transcription of Arc, Fos, and Nr4a1	Nat Neurosci. 2015 Oct;18(10):1464-73.
C2C12 cells	200 nM	24 h	JQ1 treatment prevented H2O2-induced oxidative stress, restored LC3II abundance, and reduced p62 levels.	Nat Commun. 2020 Nov 30;11(1):6108.
H2081 cells	1 µM	48 h	JQ1 significantly reduced ASCL1 and IGFBP5 expression, while having no effect on IGFBP3 expression.	Nat Commun. 2019 Jul 19;10(1):3201.

Mice	NMC 797 xenograft model	Intraperitoneal injection	50 mg/kg	Once daily for 4 days	JQ1 significantly reduces tumor growth, induces keratin expression, and inhibits tumor proliferation	Nature. 2010 Dec 23;468(7327):1067-73.
Mice	Adult male mice	Intraperitoneal injections	50 mg/kg	Daily for one week or three weeks	JQ1 treatment affected memory formation and decreased seizure susceptibility in mice	Nat Neurosci. 2015 Oct;18(10):1464-73.
Mice	Mdx mouse model	Intraperitoneal injection	20 mg/kg	Once daily for two weeks	JQ1 treatment reduced muscle damage and inflammation in mdx mice, improving muscle function.	Nat Commun. 2020 Nov 30;11(1):6108.
Mice	ASCL1High SCLC xenograft model	Intraperitoneal injection	25 mg/kg	Every other day, continuous treatment	Combination treatment of JQ1 and BMS-754807 significantly inhibited tumor growth, while monotherapy with either JQ1 or BMS-754807 had limited effects.	Nat Commun. 2019 Jul 19;10(1):3201.
Nude mice	Xenograft mouse models	Intraperitoneal injection	50 mg/kg	5 days a week, continuous treatment	To evaluate the resistance of SPOP-mutant tumors to BET inhibitor JQ1, results showed that SPOP-mutant tumors were resistant to JQ1 treatment	Nat Med. 2017 Sep;23(9):1063-1071
Mouse	Cardiomyocyte-specific BRD4 knockout mouse	Intraperitoneal injection	50mg/kg	Once daily for 2 weeks	To evaluate the effect of JQ1 on cardiac function, it was found that JQ1-treated hearts did not affect baseline cardiac function but showed protective effects in the pathological hypertrophy model.	Circulation. 2020 Dec 15;142(24):2356-2370
Zebrafish	Hepatocyte ablation model	Water treatment	3 μM	From A12h to R6h	To study the role of BET proteins in liver regeneration, it was found that JQ1 treatment temporarily inhibited liver regeneration, but regeneration resumed after washout.	J Hepatol. 2016 Feb;64(2):316-325.
Zebra fish	Transgenic zebra fish expressing human 0N/4R-Tau	Bath exposure	2 μM	Continuous exposure from 2 to 5 days	To evaluate the effects of (+)JQ1 on motor function, survival, microgliosis, and synaptic elimination in Tau zebra fish. Results showed that (+)JQ1 improved hypokinesia, increased survival, reduced microgliosis, and prevented brain synapse elimination.	Nat Commun. 2024 Sep 18;15(1):8195
C57BL/6J mice	Oxidative stress-induced retina degeneration model	Intraperitoneal injection	50 mg/kg	Daily for 3 days	JQ1 inhibited SI-induced cGAS-STING activation, reduced retina inflammation and degeneration, and improved retinal integrity.	Cell Death Differ. 2022 Sep;29(9):1816-1833
Mice	Myc-Cap model	Intraperitoneal injection	50 mg/kg	Daily, continuous treatment	To test the combined effect of JQ1 with anti-CTLA-4 immunotherapy, results showed that the combination significantly increased the CD8/Treg ratio and demonstrated a potential survival benefit.	J Immunother Cancer. 2019 Oct 25;7(1):277
Mouse	Fancd2−/− mice	Intraperitoneal injection	50 mg/kg	Daily for 1 month	Reduce DNA damage in LT-HSC, improve survival	Cell Stem Cell. 2021 Jan 7;28(1):33-47. e8
NSG mice	HCC70 xenograft model	Intraperitoneal injection and oral gavage	50 mg/kg	Once daily for 21 days	Evaluate the anti-tumor effect of JQ1 in combination with BEZ235, showing significant reduction in tumor volume and suppression of K14 expressing cell shift	Nat Commun. 2018 Sep 19;9(1):3815

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CAS No.: 1268524-70-4

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CAS No.: 1268524-70-4

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed