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Type | HazMat fee for 500 gram (Estimated) |
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Synonyms: (S)-1,1'-Bi-2,2'-naphthol; S-(-)-2,2'-Dihydroxy-1,1'-binaphthyl; (S)-(-)-1,1'-Bi-2-naphthol
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 18531-99-2 |
Formula : | C20H14O2 |
M.W : | 286.32 |
SMILES Code : | OC1=CC=C2C=CC=CC2=[C@]1[C@]3=C4C=CC=CC4=CC=C3O |
Synonyms : |
(S)-1,1'-Bi-2,2'-naphthol; S-(-)-2,2'-Dihydroxy-1,1'-binaphthyl; (S)-(-)-1,1'-Bi-2-naphthol
|
MDL No. : | MFCD00004068 |
InChI Key : | PPTXVXKCQZKFBN-UHFFFAOYSA-N |
Pubchem ID : | 11762 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H301-H315-H319 |
Precautionary Statements: | P301+P310+P330-P302+P352-P305+P351+P338 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In chloroform; at 50℃; for 0.5h;Inert atmosphere; | General procedure: A 0.5-dram vial equipped with a magnetic stirring bar wascharged with stock solutions of 2-formylphenylboronicacid (0.10 M, 200 μL, 0.02 mmol), pinacol (0.10 M, 200 μL,0.02mmol) and 5c (0.25M, 80 μL, 0.02mmol). The solventswere removed in vacuo. CHCl3 (50 μL) was added undera positive pressure of argon. The reaction was stirred at 50C for 30 min. The volatiles were then removed under highvacuum. [Pd(allyl)Cl]2 (0.13 M in CHCl3, 40 μL, 5.0 μmol)was added under a positive pressure of argon and thereaction stirred at 23C for 15 min. Allyl acetate rac-7(0.01 M in CHCl3, 10 μL, 0.10 mmol), bis(trimethylsilyl)acetamide (49 μL, 0.20 mmol), diethyl malonate (30 μL,0.20 mmol) and potassium acetate (0.50 mg, 5.0 μmol)were added sequentially. The reaction was stirred at 23Cfor 24 hours. The crude reaction mixture was then filteredthrough a short plug of Celite and rinsed three times withCH2Cl2. An aliquot of the reaction mixture (5.0 μL) wasused for conversion and ee analyses using HPLC. HPLCconditions: Chiralpak IA column, 2.0% isopropanol/hexanes,0.5 mL/min, 254 nm, tr: 22.9 and 29.2min. |