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Chemical Structure| 4727-72-4 Chemical Structure| 4727-72-4
Chemical Structure| 4727-72-4

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Product Details of 1-Benzyl-4-hydroxypiperidine

CAS No. :4727-72-4
Formula : C12H17NO
M.W : 191.27
SMILES Code : C2=C(CN1CCC(O)CC1)C=CC=C2
MDL No. :MFCD00006503
InChI Key :BPPZXJZYCOETDA-UHFFFAOYSA-N
Pubchem ID :78461

Safety of 1-Benzyl-4-hydroxypiperidine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of 1-Benzyl-4-hydroxypiperidine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4727-72-4 ]

[ 4727-72-4 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 30651-24-2 ]
  • [ 4727-72-4 ]
  • 1-benzyl-piperidin-4-yl 5-nitro-picolinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; a) 5.0 g (0.03 mol) of 5-nitro-picolinic acid (Pharmazie 38 (1983), p. 593) and 4.87 g (0.03 mol) of carbonyidiimidazole were dissolved in 250 ml of THF and stirred at 60° for 3 hours. The mixture was subsequently treated with 5.75 g (0.03 mol) of 1-benzyl-4-hydroxy-piperidine, stirred at 0°-5° for 18 hrs., at room temperature for 3 hrs. and subsequently at 40° for 2 hrs. The reaction mixture was completely freed from solvent and the residue was chromatographed over neutral Alox (grade II) with dichloromethane as the eluent and recrystallized from ethyl acetate. 4.2 g (41percent) of 1-benzyl-piperidin-4-yl 5-nitro-picolinate were obtained as yellow crystals; m.p. 175°-176°.
  • 3
  • [ 2905-56-8 ]
  • [ 3612-20-2 ]
  • [ 4727-72-4 ]
 

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