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Chemical Structure| 16034-46-1 Chemical Structure| 16034-46-1
Chemical Structure| 16034-46-1

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Product Details of 1-Methyl-5-pyrazolecarboxylic acid

CAS No. :16034-46-1
Formula : C5H6N2O2
M.W : 126.11
SMILES Code : O=C(C1=CC=NN1C)O
MDL No. :MFCD00464253
InChI Key :JREJQAWGQCMSIY-UHFFFAOYSA-N
Pubchem ID :643158

Safety of 1-Methyl-5-pyrazolecarboxylic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 1-Methyl-5-pyrazolecarboxylic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 16034-46-1 ]
  • Downstream synthetic route of [ 16034-46-1 ]

[ 16034-46-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 16034-46-1 ]
  • [ 84547-61-5 ]
YieldReaction ConditionsOperation in experiment
67% With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2 h; Inert atmosphere To a solution of 1 -methyl- lH-pyrazole-5-carboxylic acid (2 g, 15.86 mmol) in tetrahydrofuran (50 mL) was added L1AIH4 (720 mg, 18.97 mmol) in portions at 0 °C under an inert atmosphere of nitrogen. The reaction was stirred for 2 hours at room temperature then quenched by the addition of water (2 mL). The mixture was dried over by anhydrous sodium sulfate and the solids were filtered out. The filtrates were concentrated under reduced pressure to afford (1 -methyl- lH-pyrazol- 5-yl)methanol as colorless oil (1.2 g, 67 ). (ES, m/z) [M+H]+ 113.0 *H NMR (300 MHz, CDC13) δ 7.36 (d, 7 = 1.8 Hz, 1H), 6.18 (d, 7 = 1.8 Hz, 1H), 4.66 (s, 2H), 3.88 (s, 3H)
References: [1] Patent: WO2014/66795, 2014, A1, . Location in patent: Paragraph 0175.
[2] J. Gen. Chem. USSR (Engl. Transl.), 1982, vol. 52, # 11, p. 2297 - 2303[3] Zhurnal Obshchei Khimii, 1982, vol. 52, # 11, p. 2598 - 2605.
[4] Patent: WO2014/151142, 2014, A1, .
[5] Patent: WO2016/29454, 2016, A1, . Location in patent: Page/Page column 64.
 

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