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Chemical Structure| 1000339-72-9 Chemical Structure| 1000339-72-9

Structure of 1000339-72-9

Chemical Structure| 1000339-72-9

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Product Details of [ 1000339-72-9 ]

CAS No. :1000339-72-9
Formula : C6H6F3NOS
M.W : 197.18
SMILES Code : OCC1=C(C(F)(F)F)N=C(C)S1
MDL No. :MFCD09264553

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Application In Synthesis of [ 1000339-72-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1000339-72-9 ]

[ 1000339-72-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 117724-63-7 ]
  • [ 1000339-72-9 ]
YieldReaction ConditionsOperation in experiment
With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20℃; for 12.5h;Inert atmosphere; To a solution of <strong>[117724-63-7]2-methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid</strong> (0.500 g, 2.37 mmol) in THF (8 mL) was addedBH3.DMS (0.474 ml, 4.74 mmol) dropwise over 3 mm at 0 C under nitrogen. The reactionwas stirred at 0 C for 0.5 h and at 20 C for 12 h. Then the reaction was quenched slowlywith MeOH (10 mL) at 0 C. The mixture was concentrated under reduced pressure to give the title compound, which was used directly in the next step without further purification. MS (ESI) m/z: 198.0 [M+Hj ?H NMR (400MHz, DMSO-d6) oe = 6.06 (br.s, 1H), 4.74 (br. s., 2H), 2.62 (s, 3H)
 

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