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Chemical Structure| 1000895-80-6 Chemical Structure| 1000895-80-6

Structure of 1000895-80-6

Chemical Structure| 1000895-80-6

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Product Details of [ 1000895-80-6 ]

CAS No. :1000895-80-6
Formula : C7H8FNO2
M.W : 157.14
SMILES Code : OCC1=CC(OC)=NC=C1F
MDL No. :MFCD16607042

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Application In Synthesis of [ 1000895-80-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1000895-80-6 ]

[ 1000895-80-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 884495-30-1 ]
  • [ 1000895-80-6 ]
YieldReaction ConditionsOperation in experiment
77% (5-Fluoro-2-methoxy-pyridin-4-yl)methanol, used as starting material was prepared as follows:-Borane-tetrahydrofuran complex (1M solution in THF, 52.6 ml, 52.6 mmol) was added slowly to a solution of <strong>[884495-30-1]5-fluoro-2-methoxy-pyridine-4-carboxylic acid</strong> (2 g, 11.7 mmol) in THF (100 ml) under nitrogen. The reaction mixture was stirred at room temperature for 2.5 h. The solvent was then evaporated and the residue was stirred in methanol (40 ml) for 16 h. The solvent was evaporated and the residue was purified on a silica isolute column, eluting with 0-1% MeOH in DCM to afford (5-fluoro-2-methoxy-pyridin-4-yl)methanol as a white solid (1.42 g, 77% yield).1H NMR (399.902 MHz, CDCl3) delta 3.90 (s, 3H), 4.76 (s, 2H), 6.84-6.87 (m, 1H), 7.92 (d, 1H). MS: m/z 158 (MH+); (5-Fluoro-2-methoxy-pyridin-4-yl)methanol, used as starting material, was prepared as follows:-Borane-tetrahydrofuran complex (IM solution in THF, 52.6 ml, 52.6 mmol) was added slowly to a solution of <strong>[884495-30-1]5-fluoro-2-methoxy-pyridine-4-carboxylic acid</strong> (2 g, 11.7 mmol) in THF (100 ml) under nitrogen. The reaction mixture was stirred at room temperature for 2.5 h. The solvent was evaporated and the residue was stirred in methanol (40 ml) for 18 h. The solvent was evaporated and the crude product was purified by silica column chromatography, eluting with 0-1% MeOH in DCM. Pure product fractions were combined and evaporated to afford (5-fluoro-2-methoxypyridin-4-yl)methanol as a white solid (1.42 g, 77%).1H NMR (399.902 MHz, CDCl3) delta 3.90 (s, 3H), 4.76 (s, 2H), 6.84-6.87 (m, 1H), 7.92 (d, 1H); m/z (ES+) [M+H]+=158.
 

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