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Chemical Structure| 100181-71-3 Chemical Structure| 100181-71-3

Structure of 100181-71-3

Chemical Structure| 100181-71-3

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Product Details of [ 100181-71-3 ]

CAS No. :100181-71-3
Formula : C8H14O3
M.W : 158.20
SMILES Code : O=C(OCC(C)C)CC1CO1

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Application In Synthesis of [ 100181-71-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 100181-71-3 ]

[ 100181-71-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 100181-71-3 ]
  • [ 68108-18-9 ]
YieldReaction ConditionsOperation in experiment
79.3% With dmap; ammonia; In methanol; at 20℃; for 10h;Industrial scale; A solution of 15.82 g (100 mmol) of isobutyl 2-oxiranylacetate and 1.22 g (10 mmol) of 4-dimethylaminopyridine was added to a saturated solution of methanol in 200 ml of ammonia, and the mixture was stirred at room temperature for 10 hours. The organic phase was concentrated under reduced pressure and the petroleum ether was recrystallized to give 8.02 g of (S) -4-hydroxy-2-oxopyrrolidine in a yield of 79.3%, and the mixture was concentrated in 10 ml of water and extracted with ethyl acetate. , HPLC purity 99.47% (area normalization), ee value of 99.52%.
 

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