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Chemical Structure| 1002916-51-9 Chemical Structure| 1002916-51-9

Structure of 1002916-51-9

Chemical Structure| 1002916-51-9

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Product Details of [ 1002916-51-9 ]

CAS No. :1002916-51-9
Formula : C10H16N2O2
M.W : 196.25
SMILES Code : N#CC(CC1)(NC)CCC21OCCO2

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Application In Synthesis of [ 1002916-51-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1002916-51-9 ]

[ 1002916-51-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6086-21-1 ]
  • [ 1002916-51-9 ]
  • [ 1003079-39-7 ]
YieldReaction ConditionsOperation in experiment
71% Methyl-[8-(2-methyl-2H-[1,2,4]triazol-3-yl)-1,4-dioxa-spiro[4.5]dec-8-yl]-amine Butyllithium (2.5 M in hexane, 9.2 ml, 23.0 mmole) was added to a reaction vessel under an argon atmosphere and cooled to -78° C. 1-methyl-1,2,4-triazole (1.30 ml, 23 mmole) was dissolved in absolute tetrahydrofuran (60.0 ml) and added dropwise at -78° C. while cooling with ice. The reaction mixture was then stirred for 10 minutes at this temperature. 8-methylamino-1,4-dioxa-spiro[4.5]decane-8-carbonitrile (2.12 g, 10.8 mmole) in absolute tetrahydrofuran (15 ml) in a cooling bath maintained at -78° C. was then quickly added dropwise to the formed solution. After the addition the reaction solution was stirred for 1 hour in the cooling bath and was then slowly heated to 0° C. The reaction mixture was stirred overnight at room temperature. The mixture was then hydrolyzed at 0° C. with water (10 ml), the aqueous phase was extracted with chloroform (3*50 ml), and the organic phase was washed with water (50 ml) and saturated NaCl solution (50 ml), dried over Na2SO4 and concentrated by evaporation in vacuo. The product was purified by means of flash chromatography with chloroform/methanol (15:1). Yield: 1.93 g (71percent) 1H-NMR (DMSO-d6): 1.54 (2H, m); 1.72 (2H, m); 1.91 (5H, m); 2.10 (2H, m); 3.84 (4H, m); 4.01 (3H, s); 7.74 (1H, s).
 

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