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Chemical Structure| 1003560-61-9 Chemical Structure| 1003560-61-9

Structure of 1003560-61-9

Chemical Structure| 1003560-61-9

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Product Details of [ 1003560-61-9 ]

CAS No. :1003560-61-9
Formula : C8H18ClNO
M.W : 179.69
SMILES Code : CC(O)([C@H]1CNCCC1)C.[H]Cl

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Application In Synthesis of [ 1003560-61-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1003560-61-9 ]

[ 1003560-61-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75-16-1 ]
  • [ 194726-40-4 ]
  • [ 1003560-61-9 ]
YieldReaction ConditionsOperation in experiment
Methyl magnesium bromide (2 mL, 3M in diethyl ether, 6 mmol) was added dropwise to a solution of the <strong>[194726-40-4]1-tert-butyl 3-ethyl (3R)-piperidine-1,3-dicarboxylate</strong> (514 mg, 2 mmol) in diethyl ether (20 mL) and THF (20 mL) during 10 min. The mixture was stirred for 30 min and thereafter slowly quenched with NH3Cl solution (10 mL, 3M). The phases were separated and the organic phase was evaporated to yield an oil. The oil was dissolved in EtOAc (50 mL) and HCl was bubbled through the solution in a gentle stream for 10 minutes and then left at room temperature on. The solvent was evaporated and the residue dissolved in EtOAc (100 mL) and stirring for 3 h at room temperature gave a solid that was filtered off and dried in vacuum to yield the title compound as white crystals.
 

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