Alternatived Products of [ 1004558-41-1 ]
Product Details of [ 1004558-41-1 ]
CAS No. : | 1004558-41-1 |
MDL No. : | MFCD13183456 |
Formula : |
C13H14ClNO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
251.71
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1004558-41-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1004558-41-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1004558-41-1 ]
- 1
-
[ 53924-05-3 ]
-
[ 24424-99-5 ]
-
[ 1004558-41-1 ]
Yield | Reaction Conditions | Operation in experiment |
94% |
With dmap; triethylamine In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 20℃; for 11h; |
|
75% |
With dmap In dichloromethane at 25℃; for 18h; Inert atmosphere; |
|
|
With dmap In dichloromethane at 20℃; for 18h; |
8.1
Example 8: r7-Chloro-2-(4-chloro-3-cvclohexylsulfamoyl-phenvD- 1 H-indol-3 -yll -acetic acidStep 1. Di-tert-butyi dicarbonate (7.92 g) is added to a solution of 7-chloroindole (5 g) and 4- (dimethylamino) pyridine (0.4 g) in DCM (165 mL). The reaction is stirred at room temperature for 18 hr. The reaction mixture is washed with IN HCl (100 mL) and IN NHCO3 (100 mL). The organic layer is separated, dried over MgSO4 and concentrated to afford 7^ chloro-indole-l-carboxylic acid tert-butyl ester as an oil (8.22 g). |
Reference:
[1]Kirchberg, Sylvia; Froehlich, Roland; Studer, Armido
[Angewandte Chemie - International Edition, 2009, vol. 48, # 23, p. 4235 - 4238]
[2]Brown, M. Kevin; Crook, Phillip F.; Kuniyil, Rositha; Liu, Peng; Trammel, Grace L.
[Journal of the American Chemical Society, 2021, vol. 143, # 40, p. 16502 - 16511]
[3]Current Patent Assignee: SANOFI - WO2008/14186, 2008, A1
Location in patent: Page/Page column 49