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Chemical Structure| 1005-28-3 Chemical Structure| 1005-28-3

Structure of 1005-28-3

Chemical Structure| 1005-28-3

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Product Details of [ 1005-28-3 ]

CAS No. :1005-28-3
Formula : C6H8N2OS
M.W : 156.21
SMILES Code : O=CC1=CN=C(N(C)C)S1
MDL No. :MFCD03844445

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Application In Synthesis of [ 1005-28-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1005-28-3 ]

[ 1005-28-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003-61-8 ]
  • [ 74-88-4 ]
  • [ 1005-28-3 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 50℃; for 2h; To a stirring suspension of <strong>[1003-61-8]2-aminothiazole-5-carbaldehyde</strong> SM 1 (128 mg, 1 mmol) and K2C03 (346 mg, 2.5 mmol) in DMF (1 mL) was added iodomethane (284mg, 2 mmol) and heated to 50C for 2 h. After consumption of the starting material (by TLC), the reaction mixture was diluted with water and extracted with EtOAc. Combined organic extracts were dried overanhydrous Na2504 and concentrated under reduced pressure to obtain crude compound 1 (155 mg,100%) as a yellow solid, which was used for next step directly. LC-MS: m/z = 157.0 [M+H]
 

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