Home Cart 0 Sign in  

[ CAS No. 1008119-70-7 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1008119-70-7
Chemical Structure| 1008119-70-7
Structure of 1008119-70-7 * Storage: {[proInfo.prStorage]}

Quality Control of [ 1008119-70-7 ]

Related Doc. of [ 1008119-70-7 ]

SDS
Alternatived Products of [ 1008119-70-7 ]
Alternatived Products of [ 1008119-70-7 ]

Product Details of [ 1008119-70-7 ]

CAS No. :1008119-70-7 MDL No. :MFCD20265298
Formula : C11H13BFNO4 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :253.03 g/mol Pubchem ID :-
Synonyms :

Safety of [ 1008119-70-7 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1008119-70-7 ]

  • Downstream synthetic route of [ 1008119-70-7 ]

[ 1008119-70-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-91-8 ]
  • [ 120153-08-4 ]
  • [ 1008119-70-7 ]
YieldReaction ConditionsOperation in experiment
90% With HATU; In N,N-dimethyl-formamide; at 20℃; for 16h; A solution of <strong>[120153-08-4]4-borono-2-fluorobenzoic acid</strong> (1.000 g, 5.44 mmol), morpholine (0.951 mL, 10.87 mmol) and O-(7-azabenzotriazol-l-yl)-NNN',N'- tetramethyluronium hexafluorophosphate (2.103 g, 5.53 mmol) in DMF (10 mL) was stirred at room temperature for 16 h and quenched with 1 nu HCl (20 mL). Attempted extraction with EtOAc did not remove all of the product from aqueous phase. The two phases were combined, concentrated and purified by reverse phase HPLC (Sunfire SlO 30x250 mm column, 30-45% solvent B gradient) to give the expected product as white solid (1.2385 g, 90% yield). MS (ES+) m/z: 254 (M+H); LC retention time: 2.06 min (analytical HPLC Method A).
With HATU; In N,N-dimethyl-formamide; at 20℃; for 18h; (3-Fluoro-4-(morpholine-4-carbonyl)phenyl)boronic To a solution of <strong>[120153-08-4]4-borono-2-fluorobenzoic acid</strong> (1.0 g, 5.43 mmol) and HATU (2.0 g, 5.43 mmol) in DMF (20.0 mL) was added morpholine (0.9 g, 10.87 mmol) at room temperature. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was poured into ice cold water, acidified with IN HCl, extracted with EtOAc (2 x 50 mL). The organic layer was washed with brine solution (20 mL), dried over anhydrous Na2S04 and solvent was evaporated under reduced pressure to afford 1.2 g of crude compound as a colourless gum. Crude compound was directly used for the next step without any further purification.
Historical Records