Alternatived Products of [ 1009101-88-5 ]
Product Details of [ 1009101-88-5 ]
CAS No. : | 1009101-88-5 |
MDL No. : | MFCD11501889 |
Formula : |
C11H12INO2S
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
349.19
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1009101-88-5 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1009101-88-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1009101-88-5 ]
Yield | Reaction Conditions | Operation in experiment |
52% |
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- 2
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[ 1009101-88-5 ]
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[ 153624-46-5 ]
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[ 1009101-90-9 ]
Yield | Reaction Conditions | Operation in experiment |
66% |
With sodium carbonate In 1,2-dimethoxyethane; water at 85℃; for 18h; Sealed tube; |
18.B
Step B: 4'-Isopropoxy-N-(2-methylbut-3-vn-2-yl)biphenyl-4-sulfonamide: A mixture of 4-iodo-N-(2-methylbut-3-yn-2-yl)benzenesulfonamide (400 mg, 1.15 mmol), 4- isopropoxy phenyl boronic acid (309 mg, 1.72 mmol). Na2COs (364 mg, 3.44 mmol) and Pd(PPh3)4 (132 mg, 0.15 mmol) were combined in DME (7 mL) and water (2 mL), and the mixture was degassed by bubbling through nitrogen for 10 minutes. The reaction mixture was sealed (sealed tube) under nitrogen, and the reaction mixture was heated at 850C for 18 hours. After cooling to ambient temperature, EtOAc (80 mL) was added, and the organics were washed with saturated NaHCO3 (aq), brine, and dried (MgSO4). The solvents were removed in vacuo to give an orange gum. The product was purified by silica gel plug eluting with 4:1 hexanes/EtOAc. 4'-isopropoxy-N-(2-methylbut-3-yn-2-yl)biphenyl-4-sulfonamide was isolated as a pale yellow solid (270 mg, 66%). MS APCI (-) m/z 356 detected. |