Alternatived Products of [ 101055-55-4 ]
Product Details of [ 101055-55-4 ]
CAS No. : | 101055-55-4 |
MDL No. : | |
Formula : |
C8H16N2O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
156.23
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 101055-55-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 101055-55-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 101055-55-4 ]
- Downstream synthetic route of [ 101055-55-4 ]
- 1
-
[ 101055-55-4 ]
-
[ 119906-46-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 60 percent / acetone
2: 88 percent / 2N NaOH / CH2Cl2 / 2 h / Ambient temperature |
|
- 2
-
[ 630-19-3 ]
-
[ 22356-89-4 ]
-
[ 101055-55-4 ]
Yield | Reaction Conditions | Operation in experiment |
55% |
With ytterbium(III) triflate; In chloroform; for 8h;Reflux; |
General procedure: Recrystallised amino amide (1 equiv), aldehyde/ketone (2 equiv) and ytterbium trifluromethane sulfonate (0.01 equiv) were refluxed in chloroform (10 mL/mmol amino amide) for 8 h after which time the mixture was allowed to cool and the solvent evaporated. The products were purified by column chromatography. |
- 3
-
[ 24424-99-5 ]
-
[ 101055-55-4 ]
-
[ 119838-44-7 ]
-
[ 119838-38-9 ]
- 4
-
[ 34312-77-1 ]
-
[ 101055-55-4 ]
-
[ 100-52-7 ]
-
C21H25N3O3S
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
74% |
With triethylamine In toluene at 110℃; for 19h; diastereoselective reaction; |
Typical experimental procedure for 4a
General procedure: A mixture of 2-tert-butyl-3-methylimidazolidin-4-one 1a (0.1 mmol), (E)-2-nitroethenylbenzene 2a (0.1 mmol), benzaldehyde 3a (0.11 mmol), TEA (0.1mmol) in toluene (0.5mmol) was stirred for 19h at 110 °C. After completion of the reaction (TLC), the solvent was removed under vacuum. The crude product was subjected to column chromatography on silica gel using petroleum ether/ethyl acetate=6:1 as the eluent to give 4a. Compounds 4b - 4y were synthesized by a similar procedure as described for compound 4a. For the separation of these compounds, the eluent of silica gel column chromatography consisted of appropriate mixtures of petroleum ether and ethyl acetate. |
Reference:
[1]Zhang, Xia; Wang, Xiaoyan; He, Yanyang; Liu, Ying; Liu, Jie; Shi, Jianyou
[Tetrahedron Letters, 2016, vol. 57, # 10, p. 1143 - 1145]
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