Alternatived Products of [ 1013920-62-1 ]
Product Details of [ 1013920-62-1 ]
CAS No. : | 1013920-62-1 |
MDL No. : | MFCD16621191 |
Formula : |
C11H20N2O3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
228.29
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1013920-62-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1013920-62-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1013920-62-1 ]
- 1
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[ 122536-76-9 ]
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[ 75-36-5 ]
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[ 1013920-62-1 ]
Yield | Reaction Conditions | Operation in experiment |
90% |
With triethylamine In dichloromethane at 20℃; for 4h; |
8.1a
Example 8: Preparation of 5-(5-Fluoro-2-oxo-l,2-dihydro-indol-(3Z)- ylidenemethyl]-2,4-dimethyl-lH-pyrrole-3-carboxylic acid ((S)-l-acetyl- pyrrolidin-3-yl)-amidePreparation of amines for examples 8 and 9:8b 8cBocNH'9b 9c Step Ia: Compound 8a (0.5g, 2.7mmol) and TEA (0.326g, 3.2mmol) were combined in 5mL of DCM. Acetyl chloride (0.253g, 3.2mmol) was added drop- wise. The resulting mixture was stirred at room temperature for 4h and evaporated under reduced pressure. The residue was dissolved in EA and washed with aqueous 5% NaHCO3 solution and brine. The organic layer was dried over anhydrous MgSO4 and evaporated to provide crude compound 8b (0.548g, 90%), which was used directly for the next step. |
90% |
With triethylamine In dichloromethane at 20℃; for 4h; |
8.1a
Example 8 Preparation of 5-[5-Fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ((S)-1-acetyl-pyrrolidin-3-yl)-amide Preparation of Amines for Examples 8 and 9 Step 1a: Compound 8a (0.5 g, 2.7 mmol) and TEA (0.326 g, 3.2 mmol) were combined in 5 mL of DCM. Acetyl chloride (0.253 g, 3.2 mmol) was added drop-wise. The resulting mixture was stirred at room temperature for 4 h and evaporated under reduced pressure. The residue was dissolved in EA and washed with aqueous 5% NaHCO3 solution and brine. The organic layer was dried over anhydrous MgSO4 and evaporated to provide crude compound 8b (0.548 g, 90%), which was used directly for the next step. |
- 2
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[ 1013920-62-1 ]
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[ 76-05-1 ]
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[ 1013921-15-7 ]
Yield | Reaction Conditions | Operation in experiment |
|
In dichloromethane at 20℃; for 2h; |
8.2
Step 2: Compound 8b or 9b (1.0 eq.) was dissolved in DCM. TFA (10 eq.) was added slowly. The resulting mixture was stirred at room temperature for 2 h, evaporated to dryness under vacuum to provide compound 8c or 9c. |