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Chemical Structure| 1015460-56-6 Chemical Structure| 1015460-56-6

Structure of 1015460-56-6

Chemical Structure| 1015460-56-6

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Product Details of [ 1015460-56-6 ]

CAS No. :1015460-56-6
Formula : C11H7BrN2
M.W : 247.10
SMILES Code : BrC1=CC2=C(NC3=C2C=NC=C3)C=C1
MDL No. :MFCD18711547

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Application In Synthesis of [ 1015460-56-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1015460-56-6 ]

[ 1015460-56-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 26608-06-0 ]
  • [ 1015460-56-6 ]
  • C36H22N4O [ No CAS ]
  • 2
  • [ 26608-06-0 ]
  • [ 1015460-56-6 ]
  • C23H13BrN2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate; In toluene; for 2h;Reflux; Add tri-tert-butylphosphine (4.4 mL of a 1.0 M solution in toluene, 1.48 g, 0.05 mmol), palladium acetate (0.4 g, 1.83 mmol) and sodium tert-butoxide (22.8 g, 238 mmol) to 8-bromo-5H-pyrido[4,3-B]indole (45.2 g, 183 mmol) and compound a (45.7 g, 185 mmol) in EtOAc (1L). The reaction mixture was cooled to room temperature, diluted with toluene and filtered over EtOAc. The filtrate was diluted with water and extracted with toluene and the organic phases were combined and evaporated in vacuo. The residue was filtered through silica gel and recrystallized. Intermediate A135-1 (56.7 g, 75% yield) was obtained.
 

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