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Chemical Structure| 1017599-00-6 Chemical Structure| 1017599-00-6

Structure of 1017599-00-6

Chemical Structure| 1017599-00-6

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Product Details of [ 1017599-00-6 ]

CAS No. :1017599-00-6
Formula : C18H18N2O2
M.W : 294.35
SMILES Code : O=C1OC2(CCN(CC3=CC=CC=C3)CC2)C4=C1C=CN=C4

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1017599-00-6 ]

[ 1017599-00-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3612-20-2 ]
  • [ 3034-31-9 ]
  • [ 1017599-00-6 ]
YieldReaction ConditionsOperation in experiment
Reference Example 4-28 Production of 1'-benzyl-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one At -78C, a hexane solution (500 mL) of 2.71 M n-butyllithium was dropwise added to a THF solution (4.00 L) of<strong>[3034-31-9]N-phenyl-4-pyridinecarboxamide</strong> (131 g). After stirred for 2.5 hours, a THF solution (650 mL) of 1-benzyl-4-piperidone (125 g) was dropwise added to it at -78C, and stirred for 1 hour. After warmed up to -20C, aqueous 1 N sodium hydroxide solution (1.00 L) was added to it, and concentrated under reduced pressure. After extracted with ethyl acetate, the aqueous layer was made acidic (pH ~1) by adding concentrated hydrochloric acid. After stirred for 1 hour, this was neutralized (pH ~8) with aqueous 12 % potassium carbonate solution. The precipitated solid was collected through filtration, washed with water, and dissolved in chloroform. This was washed with aqueous saturated sodium hydrogencarbonate solution, and dried with anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to obtain the entitled compound (152 g) as a white solid. ESI-MS Found: m/z 295[M+H]+
 

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