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CAS No. : | 1018987-47-7 | MDL No. : | MFCD30719389 |
Formula : | C5H12ClNO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IUHDMWJWUWKOFE-JBUOLDKXSA-N |
M.W : | 153.61 | Pubchem ID : | 68644206 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: methanol 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.05 h 3: lithium borohydride / tetrahydrofuran / 23 °C 4: hydrogen; 20% palladium hydroxide-activated charcoal / ethanol / 760.05 Torr |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: lithium borohydride / tetrahydrofuran / 23 °C 2: hydrogen; 20% palladium hydroxide-activated charcoal / ethanol / 760.05 Torr |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | Stage #1: (2R,4S)-2-hydroxymethyl-4-hydroxy-N-(carbobenzyloxy)pyrrolidine With 20% palladium hydroxide-activated charcoal; hydrogen In ethanol Stage #2: With hydrogenchloride In methanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate In tetrahydrofuran; methanol at 80℃; for 17h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate In tetrahydrofuran; methanol at 80℃; for 17h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: anhydrous sodium carbonate / 1,4-dioxane; lithium hydroxide monohydrate / 10 - 20 °C 2.1: triethylamine; chloroformic acid ethyl ester / dichloromethane / 1 h / -30 °C / Inert atmosphere 2.2: 1 h / 0 °C / Inert atmosphere 3.1: hydrogenchloride / ethyl acetate / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With hydrogenchloride In ethyl acetate at 20℃; | 3 Step 3: Compound 2 (315 g, 1.45 mol) was added to the 3 L reaction bottle, ethyl acetate (300 mL) was added to dissolve, 2N HCl of ethyl acetate solution (1.5 L) was added dropwise, stirred overnight at room temperature, filtered, ethyl acetate (1 L) was leached, the filter cake was dried to obtain a white solid, and the target compound 3 (210 g, 1.37 mol, 95%). |
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