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Chemical Structure| 1019650-76-0 Chemical Structure| 1019650-76-0

Structure of 1019650-76-0

Chemical Structure| 1019650-76-0

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Product Details of [ 1019650-76-0 ]

CAS No. :1019650-76-0
Formula : C9H11N3O
M.W : 177.20
SMILES Code : O=C1N(C2=CC(N)=NC=C2)CCC1

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Application In Synthesis of [ 1019650-76-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1019650-76-0 ]

[ 1019650-76-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 616-45-5 ]
  • [ 552331-00-7 ]
  • [ 1019650-76-0 ]
YieldReaction ConditionsOperation in experiment
45% With potassium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 100℃; for 14h;Inert atmosphere; Reference Example 3; 1-(2-aminopyridin-4-yl)pyrrolidin-2-oneA solution of <strong>[552331-00-7]4-iodopyridin-2-amine</strong> (440 mg, 2 mmol) obtained in Reference Example 2, pyrrolidin-2-one (387 mg, 2.4 mmol), potassium carbonate (553 mg, 4 mmol), copper iodide (76 mg, 0.4 mmol) and N,N'-dimethylethylenediamine (43 mul, 0.4 mmol) in dioxane (10 ml) was stirred at 100 C. for 14 hr under an argon atmosphere. Water was added to the mixture, and the mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous sodium hydrogensulfate. The solvent was evaporated under reduced pressure. The residue was crystallized from ethanol to give the title compound (160 mg, yield 45%).1H-NMR (CDCl3) delta: 2.17 (2H, tt, J=7.8, 6.9 Hz), 2.62 (2H, t, J=7.8 Hz), 3.82 (2H, t, J=6.9 Hz), 4.44 (2H, brs), 6.78 (1H, d, J=5.8, 1.9 Hz), 7.09 (1H, d, J=1.9 Hz), 8.01 (1H, d, J=5.8 Hz).
 

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