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Chemical Structure| 10236-10-9 Chemical Structure| 10236-10-9

Structure of 10236-10-9

Chemical Structure| 10236-10-9

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Product Details of [ 10236-10-9 ]

CAS No. :10236-10-9
Formula : C9H18O2
M.W : 158.24
SMILES Code : CC(C)CCCC(OCC)=O
MDL No. :MFCD02258638

Safety of [ 10236-10-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P210-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 10236-10-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10236-10-9 ]

[ 10236-10-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10236-10-9 ]
  • [ 658-27-5 ]
  • ethyl 1-(3-fluorophenyl)-3-isobutyl-1H-pyrazole-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
135 mg Take 50 ml round-bottom flask, the intermediate diethyl carbonate ester (1.77g, 14 . 98mmol) dissolved in 15mLTHF in, low-temperature, add 60% NaH (480 mg, 11 . 98mmol), stirring the mixture at room temperature for 30 minutes; slowly added 4-methyl-2-pentanone (1g, 9.98mmol), 60 C heating reaction 4h. After the reaction cooled to room temperature, add 50 ml acetic acid aqueous solution quenching, ethyl acetate extraction three times (25mLx3), combined with the phase, 50 ml saturated sodium bicarbonate aqueous solution and a, 50 ml of a saturated salt water, drying by anhydrous sodium sulfate; and concentrated to obtain crude 4-methyl butyryl ethyl acetate, directly proceeding to the next step.Taking 25 ml round-bottom flask, the crude product of step 4-methyl butyryl ethyl acetate soluble (1g, 5.81mmol) 5mLN, dipropylene N-dimethyl formamide methanol 100 C stirring overnight. After the reaction is distilled under reduced pressure to obtain a yellow oily liquid.Taking 25 ml round-bottom flask, intermediate the upper step (335 mg, 1 . 47mmol) is dissolved in 6 ml ethanol, adding triethylamine (622 mg, 6 . 14mmol), <strong>[658-27-5]3-fluorophenylhydrazine</strong> hydrochloride compound (200 mg, 1 . 23mmol), the reaction room temperature for 2 hours. After the reaction is ended, part of the ethanol is removed by reduced pressure distillation, add 50 ml water, ethyl acetate extraction three times (25mLx3), combined with the phase, 50 ml of a saturated salt water, drying by anhydrous sodium sulfate; concentrated, dry sample, rapid preparation of chromatographic silica gel column (ethyl acetate: petroleum ether = 30:1) separated to obtain oily liquid 135 mg, yield 38%.
 

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