Alternatived Products of [ 1025718-96-0 ]
Product Details of [ 1025718-96-0 ]
CAS No. : | 1025718-96-0 |
MDL No. : | MFCD12405448 |
Formula : |
C12H19BO3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
222.09
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 1025718-96-0 ]
Application In Synthesis of [ 1025718-96-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1025718-96-0 ]
- 1
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[ 72407-17-1 ]
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[ 1025718-96-0 ]
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C17H16ClNO3
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
65% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 110℃; for 3h;Microwave irradiation; |
To A solution of intermediate l-04a (1 .6 g, 4.52 mmol) in 1 ,4-dioxane/H20 (10:1 , 1 1 mL) was added K2C03(1 .25 g, 9.04 mmol), Pd(PPh3)4(0.53 g, 0.452 mmol) and methylboronic acid (R-02a, 0.30 g, 4.98 mmol) and the solution was heated to 1 10 C for 3 hours under Microwave. Then the mixture was concentrated and extracted with EtOAc. The combined organic layers were washed with brine, dried over anhydrous Na2S04.filtered and concentrated to give the crude product which was purified by column chromatography (Si02, DCM/MeOH = 1 :0 to 4:1 ) to give pure intermediate l-05a (0.18 g, 12%) as a yellow solid. ESI-MS (M+1 ): 335 calc. for Ci8H23CIN202: 334.1 . |