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Chemical Structure| 1028634-76-5 Chemical Structure| 1028634-76-5

Structure of 1028634-76-5

Chemical Structure| 1028634-76-5

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Product Details of [ 1028634-76-5 ]

CAS No. :1028634-76-5
Formula : C36H50N6O5
M.W : 646.82
SMILES Code : C(N(C[C@@H]([C@H](CC1=CC=CC=C1)NC([C@@H](NC(OC)=O)[C@](C)(C)C)=O)O)NC([C@H](C(C)(C)C)N)=O)C2=CC=C(C=C2)C3=CC=CC=N3
MDL No. :N/A

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Application In Synthesis of [ 1028634-76-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1028634-76-5 ]

[ 1028634-76-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1028634-76-5 ]
  • [ 79-22-1 ]
  • [ 198904-31-3 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0℃; for 2.5h; Example 6 - Preparation of Atazanavir Compound (8) (9.47 g), obtained according to example 5, was suspended in 200 mL of CH2Cl2, added with 1.99 g of diisopropyl ethylamine, and the resulting mixture was cooled to about 0C. 1.45 g of methyl chloroformate in 25 mL of CH2Cl2 were added dropwise over about 2 hours. The suspension was then stirred for about half an hour at 0C and added with an aqueous solution of 10% NaHCO3 (100 mL) at 0C with vigorous stirring. The organic phase was the separated, dried over anhydrous sodium sulphate, filtered and evaporated in vacuo to afford 8.46 g of a white solid, which was hot-crystallized from ethanol (65 mL) and water (33 mL). The resulting solid was filtered, washed on the filter with an ethanol/water mixture and dried, to obtain 5.1.g of Atazanavir as a white solid.
 

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