Alternatived Products of [ 1029421-36-0 ]
Product Details of [ 1029421-36-0 ]
CAS No. : | 1029421-36-0 |
MDL No. : | MFCD28405312 |
Formula : |
C8H5BrFNO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | JIHABKIDCVPCNQ-UHFFFAOYSA-N |
M.W : |
246.03
|
Pubchem ID : | 59298370 |
Synonyms : |
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Safety of [ 1029421-36-0 ]
Application In Synthesis of [ 1029421-36-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1029421-36-0 ]
- 1
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[ 1029421-36-0 ]
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[ 1446001-98-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: copper(l) iodide / methanol / 20 h / 80 °C
2: boron tribromide / dichloromethane / 17 h / 0 - 20 °C |
|
- 2
-
[ 1029421-36-0 ]
-
[ 1446001-99-5 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: copper(l) iodide / methanol / 20 h / 80 °C
2: boron tribromide / dichloromethane / 17 h / 0 - 20 °C
3: borane-THF / tetrahydrofuran / 17 h / 20 °C |
|
- 3
-
[ 1029421-36-0 ]
-
[ 1446002-00-1 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: copper(l) iodide / methanol / 20 h / 80 °C
2: boron tribromide / dichloromethane / 17 h / 0 - 20 °C
3: borane-THF / tetrahydrofuran / 17 h / 20 °C
4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 19 h / 60 °C |
|
- 4
-
[ 1029421-36-0 ]
-
[ 1446002-01-2 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 5 steps
1: copper(l) iodide / methanol / 20 h / 80 °C
2: boron tribromide / dichloromethane / 17 h / 0 - 20 °C
3: borane-THF / tetrahydrofuran / 17 h / 20 °C
4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 19 h / 60 °C
5: sodium t-butanolate; ruphos; (2-dicyclohylphosphino-2'6'-diisopropyl-1 1'-biphenyl)(2-(2-aminoethyl)phenyl)palladium(II) / 1,4-dioxane / 23 h / 100 °C / Inert atmosphere; Sealed tube |
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- 5
-
[ 1029421-36-0 ]
-
[ 1446002-02-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 6 steps
1: copper(l) iodide / methanol / 20 h / 80 °C
2: boron tribromide / dichloromethane / 17 h / 0 - 20 °C
3: borane-THF / tetrahydrofuran / 17 h / 20 °C
4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 19 h / 60 °C
5: sodium t-butanolate; ruphos; (2-dicyclohylphosphino-2'6'-diisopropyl-1 1'-biphenyl)(2-(2-aminoethyl)phenyl)palladium(II) / 1,4-dioxane / 23 h / 100 °C / Inert atmosphere; Sealed tube
6: hydrogenchloride / dichloromethane; 1,4-dioxane / 72 h / 20 °C |
|
- 6
-
[ 1029421-36-0 ]
-
[ 1446001-56-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 7 steps
1.1: copper(l) iodide / methanol / 20 h / 80 °C
2.1: boron tribromide / dichloromethane / 17 h / 0 - 20 °C
3.1: borane-THF / tetrahydrofuran / 17 h / 20 °C
4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 19 h / 60 °C
5.1: sodium t-butanolate; ruphos; (2-dicyclohylphosphino-2'6'-diisopropyl-1 1'-biphenyl)(2-(2-aminoethyl)phenyl)palladium(II) / 1,4-dioxane / 23 h / 100 °C / Inert atmosphere; Sealed tube
6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 72 h / 20 °C
7.1: HATU; triethylamine / dichloromethane / 0.33 h / 20 °C
7.2: 1.5 h / 20 °C |
|
- 7
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[ 1029421-36-0 ]
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[ 124-41-4 ]
-
[ 1446001-97-3 ]
Yield | Reaction Conditions | Operation in experiment |
92% |
With copper(l) iodide In methanol at 80℃; for 20h; |
I1.a a) 5-Fluoro-6-methoxy-4H-benzo[1,4]oxazin-3-one
a) 5-Fluoro-6-methoxy-4H-benzo[1,4]oxazin-3-one A solution of 6-bromo-5-fluoro-4H-benzo[1,4]oxazin-3-one (CAS registry 1029421-36-0) (5.0 g, 20 mmol) in MeOH (10 ml) was treated with sodium methoxide solution (30% in MeOH, 11.3 ml, 61 mmol) and CuI (0.4 g, 2 mmol). After stirring for 20 h at 80° C., the reaction was quenched with sat. aq. NaHCO3 soln and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure to obtain a pale yellow solid. (2.2 g, 92% yield). UPLC RtM1=0.64 min. 1H NMR (400 MHz, DMSO-d6): δ 6.74 (m, 2H), 4.53 (s, 2H), 3.79 (s, 3H). |