Home Cart 0 Sign in  

[ CAS No. 1032349-98-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1032349-98-6
Chemical Structure| 1032349-98-6
Structure of 1032349-98-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1032349-98-6 ]

Related Doc. of [ 1032349-98-6 ]

Alternatived Products of [ 1032349-98-6 ]

Product Details of [ 1032349-98-6 ]

CAS No. :1032349-98-6 MDL No. :MFCD20274497
Formula : C23H27NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 365.47 Pubchem ID :-
Synonyms :

Safety of [ 1032349-98-6 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 1032349-98-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1032349-98-6 ]

[ 1032349-98-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 893423-62-6 ]
  • [ 1032349-98-6 ]
  • [ 1032349-99-7 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 120℃; for 16h;Product distribution / selectivity; tert-butyl{1-[4-(5-chloro-3-phenyl-1,6-naphthyridin-2-yl)phenyl]cyclobutyl}carbamate (1-5) To a round bottom flask was added tert-butyl{1-[4-(phenylacetyl)phenyl]cyclobutyl}carbamate (1-3) (2.7 g, 6.1 mmol), <strong>[893423-62-6]tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate</strong> (1-4) (1.6 g, 6.1 mmol), potassium carbonate (5.0 g, 6.0 mmol), and DMF (20 mL). The reaction mixture was heated to 80 C. while stirring in a hot oil bath under an atmosphere of nitrogen for 15 hours. Then the reaction mixture was warmed to 120 C. for 1 hour. The reaction mixture was permitted to cool to room temperature, added water, suspended in ethyl acetate, washed with a saturated solution of sodium bicarbonate, followed by water, brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The resulting residue was purified by silica gel chromatography (5-50% EtOAc/5% DCM/Hexane) to give tert-butyl{1-[4-(5-chloro-3-phenyl-1,6-naphthyridin-2-yl)phenyl]cyclobutyl}carbamate (1-5) as an off-white solid. HRMS (M+H)+: observed=486.1954, calculated=486.1943.
With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 120℃; for 16h;Inert atmosphere; To a round bottom flask was added tert-butyl { 1 [4(phenylacetyl)phenyl] cyclobutyl} carbamate (6-3) (2.7 g, 6.1 mmol), tert-butyl (2-chloro-3-formylpyridin-4- yl)carbamate (1-5) (1.6 g, 6.1 mmol), potassium carbonate (5.0 g, 6.0 mmol), and finally DMF (20 mL). The reaction mixture was heated to 800C while stirring in a hot oil bath under an atmosphere of nitrogen for 15 hours. Then the reaction mixture was warmed to 1200C for 1 hour. The reaction mixture was then permitted to cool to room temperature, added water (20 mL), suspended in ethyl acetate, washed with a saturated solution of sodium bicarbonate, followed by water, then brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The resulting residue was purified by silica gel chromatography (5-50% EtO Ac/5 %DCM/ Hexane) to give tert-butyl { 1 - [4-(5 -chloro-3 -phenyl- 1 ,6-naphthyridin-2-yl)phenyl] cyclobutyl} carbamate (6-4) as an off-white solid. HRMS (M+H)+: observed = 486.1954, calculated = 486.1943
  • 2
  • [ 1032349-98-6 ]
  • [ 1402608-02-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 0 °C 2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / Reflux 3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 2 h / 20 °C 3.2: pH > 7 / Cooling with ice 4.1: ammonia / methanol / 5 h / 130 °C / Microwave irradiation
  • 3
  • [ 50921-39-6 ]
  • [ 1032349-98-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: sodium azide; tetrabutylammomium bromide; zinc trifluoromethanesulfonate / tetrahydrofuran / 18 h / 60 °C / Inert atmosphere 2.1: bis(tri-t-butylphosphine)palladium(0) / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere 3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 3.2: -78 - 0 °C 3.3: 0 °C
Same Skeleton Products
Historical Records