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Chemical Structure| 1032570-71-0 Chemical Structure| 1032570-71-0

Structure of 1032570-71-0

Chemical Structure| 1032570-71-0

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Product Details of [ 1032570-71-0 ]

CAS No. :1032570-71-0
Formula : C11H12N4O2
M.W : 232.24
SMILES Code : OC1=C(OC)C2=C(C=C1)C3=NCCN3C(N)=N2
MDL No. :MFCD28502376

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Application In Synthesis of [ 1032570-71-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1032570-71-0 ]

[ 1032570-71-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1032570-71-0 ]
  • [ 57616-74-7 ]
  • [ 1032570-74-3 ]
YieldReaction ConditionsOperation in experiment
86% In water; N,N-dimethyl-formamide; at 90℃; for 5h;Large scale; Example 8a : Step A8 : Method A : preparation of 7-methoxy-8-[3- (morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1 ,2-c]quinazolin-5-amine (9) : 2.5 kg of potassium carbonate were added to a mixture of 1 .4 kg of 5-amino-7- methoxy-2,3-dihydroimidazo[1 ,2-c]quinazolin-8-ol, 14 L of n-butanol, 1 .4 L of Nu,Nu-dimethylformamide and 1 .4 L of water. 1 .57 kg of 4-(3- chloropropyl)morpholine hydrochloride were added. The resulting suspension was heated to 90C and stirred at this temperature for 5 h. The mixture was cooled to r.t.. At 50C 8.4 kg of water were added. The mixture was stirred at r.t. for 15 min. After phase separation the aqueous phase was extracted with 12 L of n-butanol. The combined organic phases were concentrated in vacuum to a volume of ap. 1 1 L. 10.7 L of terf-butyl methyl ether were added at 50C. The resulting mixture was cooled within 2 h to 0C and stirred at this temperature for 1 h. The suspension was filtered, and the collected solids were washed with tert- butyl methyl ether and dried to give 1 .85 kg (86 %).
 

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