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Chemical Structure| 10336-11-5 Chemical Structure| 10336-11-5

Structure of 10336-11-5

Chemical Structure| 10336-11-5

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Product Details of [ 10336-11-5 ]

CAS No. :10336-11-5
Formula : C7H6N2Se
M.W : 197.10
SMILES Code : NC1=CC=C([Se]C#N)C=C1

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Application In Synthesis of [ 10336-11-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10336-11-5 ]

[ 10336-11-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10336-11-5 ]
  • [ 40724-47-8 ]
  • 4-(((4-aminophenyl)selanyl)methyl)benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% General procedure: NaBH4 (0.80 mmol, 4.0 eq.) was portionwise added to a solution of arylselenocyanates 5a-b (0.20 mmol, 1.0 eq.) in EtOH (5 mL) at room temperature under inert atmosphere (N2). After 1 h, sulphonamide 6 (0.20 mmol, 1.0 eq.) was slowly added and the reaction mixture was stirred at room temperature for 3 h, until complete consumption of the starting material was observed by TLC. The reaction was quenched by addition of saturated aq. NH4Cl (4 mL) and diluted with EtOAc (5 mL). The layers were separated and the aqueous layer was extracted with EtOAc (2 x 5 mL), dried over Na2SO4, filtered and concentrated under vacuum. The crude material was purified by flash chromatography (hexane/EtOAc 1:1) to yield selenides 7c-d. 4.1.7. 4-(((4-aminophenyl)selanyl)methyl)benzenesulfonamide 7c. Following the general procedure, 4-selenocyanatoaniline 5a (40 mg, 0.20 mmol) and <strong>[40724-47-8]4-(bromomethyl)benzenesulfonamide</strong> 6 (50 mg, 0.20 mmol) gave after flash chromatography (hexane/EtOAc 1:1) 7c (58 mg, 85percent). 1H NMR (400 MHz, DMSO-d6) delta (ppm):7.70 (2H, d, J = 8.36 Hz), 7.36-7.29 (4H, m), 7.12 (2H, d, J = 8.51 Hz), 6.50 (2H, d, J = 8.53 Hz), 5,32 (2H, bs, NH2, exchange with D2O), 4.05 (2H, s). 13C NMR (100 MHz, DMSO?d6) delta (ppm): 149.8, 145.0, 143.0, 136.9, 129.8, 126.4, 115.5, 113.3, 32.5. 77Se NMR (76 MHz, DMSO?d6) delta (ppm): 370.7. MS (ESI negative) m/z: 341.2 [M-H]-.
 

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