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Chemical Structure| 1034895-78-7 Chemical Structure| 1034895-78-7

Structure of 1034895-78-7

Chemical Structure| 1034895-78-7

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Product Details of [ 1034895-78-7 ]

CAS No. :1034895-78-7
Formula : C11H13NO
M.W : 175.23
SMILES Code : CN1C=CC2=C1C(COC)=CC=C2

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Application In Synthesis of [ 1034895-78-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1034895-78-7 ]

[ 1034895-78-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1074-87-9 ]
  • [ 74-88-4 ]
  • [ 1034895-78-7 ]
YieldReaction ConditionsOperation in experiment
89% With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20℃; for 1.0h; To a solution of (1 H-indol-7-yl)-methanol (0.50 g, 3.40 mmol) in dry DMF (6 ml_) cooled at 0 0C was added NaH (0.41 g, 10.19 mmol, 55% suspension in mineral oil), followed by methyl iodide (0.50 ml_, 8.15 mmol). The reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into ice-water and the solution was extracted with ethyl acetate. The ethyl acetate extract was dried over anhydrous Na2SO4, concentrated in vacuo and purified by column chromatography (ethylacetate:hexane; 1 :9) to afford the product (0.53 g, 89%) as slightly yellow oil.[000294] 1H NMR (CDCI3, 400 MHz) 3.36 (s, 3H), 4.04 (s, 3H), 4.77 (s, 2H), 6.46 (d, J=4.0 Hz, 1 H), 6.95-7.08 (m, 3H), 7.59 (dd, J=2.0, 8.0 Hz, 1 H), 13C NMR (CDCI3, 100 MHz) 35.4, 56.7, 72.7, 100.7, 118.4, 120.2, 121.5, 124.7, 129.9, 130.2, 134.6.
 

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