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Chemical Structure| 103577-65-7 Chemical Structure| 103577-65-7

Structure of 103577-65-7

Chemical Structure| 103577-65-7

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Product Details of [ 103577-65-7 ]

CAS No. :103577-65-7
Formula : C8H8F3NO2
M.W : 207.15
SMILES Code : OCC1=NC=CC(OCC(F)(F)F)=C1
MDL No. :MFCD14606384

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Application In Synthesis of [ 103577-65-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 103577-65-7 ]

[ 103577-65-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 98197-88-7 ]
  • [ 75-89-8 ]
  • [ 420-87-1 ]
  • [ 103577-65-7 ]
YieldReaction ConditionsOperation in experiment
79% for 38h;Reflux; A (0128) 100-mL round-bottom flask was charged with <strong>[98197-88-7](4-nitropyridin-2-yl)methanol</strong> (1.02 g, 6.63 mmol), CF3CH2OH (17 mL), and CF3CH20Na (3.07 g, 25.2 mmol, 3.8 equiv, prepared from CF3CH2OH and NaH). A reflux condenser was atached, and after the reaction mixture was heated to reflux for 14 h, the reaction mixture was cooled to 23 C, and additional CFsCHteOIMa (2.04 g, 16.7 mmol, 2.5 equiv) was added. The reaction mixture was heated to reflux for 24 h, cooled to 23 C, and neutralized with aqueous 4.0 M HCI. The mixture was concentrated in vacuo. The resulting residue was dissolved in saturated aqueous NaHCOa, and the product was extracted with EtOAc (3 c 30 mL) using a separatory funnel. The combine organic layers were dried over anhydrous NaaSCU, filtered, and concentrated in vacuo to deliver (4-(2,2,2~trifuoroethoxy)pyridin~2- yl)methanol (1.08 g, 79% yield).
 

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