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Chemical Structure| 1036761-88-2 Chemical Structure| 1036761-88-2

Structure of 1036761-88-2

Chemical Structure| 1036761-88-2

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Product Details of [ 1036761-88-2 ]

CAS No. :1036761-88-2
Formula : C11H13N3O
M.W : 203.24
SMILES Code : N1(C2=CC3=NC=CN3C=C2)CCOCC1
MDL No. :MFCD22573699

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Application In Synthesis of [ 1036761-88-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1036761-88-2 ]

[ 1036761-88-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-91-8 ]
  • [ 4532-25-6 ]
  • [ 1036761-88-2 ]
YieldReaction ConditionsOperation in experiment
With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 80℃; Procedure E; To a solution of 7-Chloro-imidazo[1 ,2-a]pyridine (1.0g, 6.58mmol) in anhydrous dioxane (60ml) was added morpholine (0.64ml, 6.58mmol), NaO'Bu (1.9g, 19.74mmol) [reaction degassed by bubbling N2 through] followed by BINAP (0.43g, 0.69mmol) and Pd2dba3 (tris- (dibenzylideneacetone)dipalladium(O)) (0.32g, 0.36mmol). The mixture was heated at 80 0C overnight, then diluted with water and extracted with EtOAc. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The crude <n="102"/>residue was purified by silica chromatography to give the desired product (0.55g) MS: [M+H]+ 204.
 

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