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CAS No. : | 4532-25-6 | MDL No. : | MFCD08275126 |
Formula : | C7H5ClN2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | NGHRUBVFDAKWBC-UHFFFAOYSA-N |
M.W : | 152.58 | Pubchem ID : | 19695901 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 9 |
Fraction Csp3 : | 0.0 |
Num. rotatable bonds : | 0 |
Num. H-bond acceptors : | 1.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 40.2 |
TPSA : | 17.3 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.53 cm/s |
Log Po/w (iLOGP) : | 1.87 |
Log Po/w (XLOGP3) : | 2.39 |
Log Po/w (WLOGP) : | 1.99 |
Log Po/w (MLOGP) : | 1.32 |
Log Po/w (SILICOS-IT) : | 1.63 |
Consensus Log Po/w : | 1.84 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.96 |
Solubility : | 0.168 mg/ml ; 0.0011 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.39 |
Solubility : | 0.615 mg/ml ; 0.00403 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.68 |
Solubility : | 0.316 mg/ml ; 0.00207 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.44 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With sodium hydrogencarbonate In ethanol; water at 20℃; for 20 h; Reflux | Synthesis of 7-Chloroimidazo[1 , 2-a]pyridine (compound 65-3)[0000229] To a suspension of compound 65-2 (HC1) in ethanol (15 mL) was added sodium bicarbonate powder (3.3g, 38.4 mmol, 4 equiv) and a 50percent solution of chloroacetaldehyde in water (2.26 g, 14.4 mmol, 1.5 equiv) . The reaction was heated at reflux for 4 hours and stirred at room temperature for 16 hours. The reaction was concentrated under reduced pressure and the residue was dissolved in water (10 mL) and ethyl acetate (10 mL) . The layers were separated and the aqueous phase was extracted with ethyl acetate (2 x 5 mL) . The organic layers were combined, dried over sodium sulfate, filtered and concentrated to give compound 65-3 as a dark yellow oil (980 mg, 89percent yield) |
85% | for 2 h; Reflux | (2a) 7-Chloroimidazo[1,2-a]pyridine Into ethanol (50 mL), 2-amino-4-chloropyridine (643 mg, 5.00 mmol) was dissolved, to which a 40percent aqueous solution of chloroacetaldehyde (8.25 mL, 50 mmol) was added, followed by heating under reflux for two hours. The resulting mixture was left to cool, and the solvent was distilled off under reduced pressure. The residue thus obtained was purified by basic silica gel column chromatography (dichloromethane) to give the desired title compound (645 mg, yield 85percent). 1H-NMR (CDCl3) δ: 6.79 (1H, dd, J = 7.4, 2.3 Hz), 7.57 (1H, s), 7.63 (2H, br s), 8.05 (1H, d, J = 7.4 Hz). |
79% | at 130℃; for 12 h; | General procedure: 2-aminopyridine (15 g, 0.159 M) was dissolved in 1-butanol (64 mL) in a 250 mL round bottom flask affixed with a magnetic stir bar. 2-chloroacetaldehyde 50percent solution in water (24.3 mL, 0.191 M) was added hitherto and the reaction was heated to 130 °C for 12 h.The reaction solvent was condensed in vacuo and the crude product was adsorbed onto silica. The product was purified via flash chromatography utilizing a DCM/MeOH gradient and isolated as a light, yellow oil (17 g, 90percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
15% | With sodium hydrogencarbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; benzene; at 100℃; for 67h; | Combine 7-chloro-imidazo [1, 2-a] pyridine (PCT Appl. WO 01/38326 A2; 134 mg, 0.88 mmol) with 2- (pyridin-2-yl)-5, 6-dihydro-4H-pyrrolo [1, 2-b] pyrazole-3-boronic acid (Preparation 5; 369 mg, 0.97 mmol) in the presence of tetrakis (triphenylphosphine) palladium (0) (30 mg, 0.03 mmol) and 2M aqueous sodium bicarbonate (1.0 mL) in benzene (2.1 mL) and ethanol (0.3 mL). Heat the mixture for 67 h at 100 C. Dilute the reaction with methylene chloride (10 mL) and water (10 mL). Separate the layers and extract the aqueous layer with methylene chloride (2 x 10 mL). Combine the organic layers and dry over sodium sulfate. Filter the solution and evaporate the solvent. Purify the crude product by flash chromatography using the appropriate ammonia in methanol/methylene chloride mixture to give the title compound as a tan solid (41 mg, 15%). MS m/e (302.0, M+1). 1H NMR (CDC13) 8 8.57 (m, 1 H), 7.96 (dd, J = 1, 7 Hz, 1 H), 7.6 (m, 5 H), 7.19 (m, 1 H), 6.69 (dd, J = 1, 7 Hz, 1 H), 4.27 (t, J=8HZ, 2H), 3.08 (t, J=7HZ, 2H), 2.71 (q, J=7HZ, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | Combine <strong>[4532-25-6]7-chloro-imidazo[1,2-a]pyridine</strong> (500.4 g, 3.28 mol), bis(pinacolato)diboron (999 g; 3.93 mol), tricyclohexylphosphine (92 g; 328.06 mmoles), and potassium acetate (483 g; 4.92 mol), in diglyme (4 L) and water (4.83 mL) and stir for 5 min. Add palladium (II) acetate (36.81 g; 163.96 mmoles) and more diglyme (1 L) and heat to 100 C. for 17 hours. Cool the reaction and add potassium carbonate (340 g; 2.46 moles) and stir 18 hr. Filter reaction slurry and wash solids with diglyme (2*1 L). Slurry the solids in water (5 L) and then filter and wash with water (2*1 L) and heptane (1 L). Dry the solid in a vacuum oven at 60 C. to afford 695.1 g (90%) of the titled product. MS (m/z): 245 (M+1). | |
With potassium acetate;tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; In 1,4-dioxane; at 80℃; | Preparation 27; 3-Iodo-7-pyridin-2-yl-imidazo[l,2-a]pyridine A. 7-Pyridin-2-yl-imidazo[l,2-a]pyridineTo a round bottomed flask add 7-chloro-imidazo[l,2-a]pyridine (0.25 g, 1.6 mmol), tricyclohexylphosphine (55 mg, 0.12 equiv.), potassium acetate (0.24 g, 1.5 equiv.), bis(pinacolato)diboron (0.46 g, 1.1 equiv.) and dioxane (10 mL). Deoxygenate this mixture thoroughly with N2 then add tris(dibenzylideneacetone)dipalladium (0) (75 mg, 0.05 equiv.) and heat the reaction to 80 C overnight under N2. Filter the reaction thru Celite and wash with DCM then concentrate to dryness. To this residue, add 2- bromopyridine (0.14 mL, 1.5 mmol), S-Phos (75 mg, 0.125 equiv.), potassium phosphate (0.62 g, 2 equiv.), dioxane (10 mL), and water (5 mL). Deoxygenate this mixture thoroughly with N2, add palladium (II) acetate (16 mg, 0.05 equiv.), and reflux the reaction overnight. Concentrate the reaction to dryness and slurry in DCM. Filter this slurry thru Celite and wash with DCM. Concentrate the filtrate then purify by silica column (EtOAc to 5% MeOH : DCM) to give a residue (0.325 g, >100 %). MS (ES), m/z 196 (M+l). | |
With potassium carbonate; tricyclohexylphosphine;palladium diacetate; In water; diethylene glycol; at 100℃; for 15h;Inert atmosphere; | 7-Chloro-imidazo[1,2-a]pyridine (10 g; 65.54 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi-1,3,2-dioxaborolane (19.93 g; 78.65 mmol), K2CO3 (13.59 g; 98.31 mmol), tricyclohexylphosphine (1.84 g; 6.55 mmol), Palladium acetate (47% Pd) (0.74 g; 3.28 mmol) in 2-methoxyethylether (100 ml) and water (0.13 ml) were heated to 100 C. for 15 hours under N2. The reaction mixture was cooled to room temperature. The mixture was cooled to 5 C., filtered, washed the cake with 2×10 ml of water and poured into in 50 ml of water then filtered and the insoluble was washed with 2×20 ml of water, dried to give 11.25 g (70.396) of intermediate shown. |
With potassium carbonate; tricyclohexylphosphine;palladium diacetate; In water; at 100℃; | To a solution of 7-chloroimidazo-[1 ,2,a]pyridine (10 g, 65.5 mmol) and bis(pinocolato)diboron (20 g, 78.7 mmol) in diglyme (100 ml) were added K2CO3 (13.5 g, 97.7 mmol), palladium (II) acetate (730 mg, 3.25 mmol), tricyclohexylphosphine (1.8 g, 6.42 mmol) and water (0.14 ml). The resulting mixture was heated at 100 0C overnight under an inert atmosphere, diluted with water (50 ml) and stirred for 1 h at room temperature. The precipitate was separated by filtration, washed with diglyme/water (2/1 , 30 ml) and water (20 ml) then dried to generate the product (7.58 g) as a grey powder. MS: [M+H]+ = 246. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With N-iodo-succinimide; In acetonitrile; for 0.5h; | Preparation 22; 3-Iodo-7-chloro-imidazo[l,2,a]pyridineTo a solution of 7-chloro-imidazo[l,2,a]pyridine (6.10 g, 40 mmol) (Yamanaka, Motosuke et al., Chemical & Pharmaceutical Bulletin (1991), 39(6), 1556-67) in dry acetonitrile (100 mL), add N-iodosuccinamide. Stir for 30 minutes. Filter off the precipitate and then wash with acetonitrile. Recrystallize the precipitate from acetonitrile to give a white solid. Concentrate the filtrate, dilute with ethyl acetate, wash with 10% sodium hydrogensulfite (NaHSO3), saturated aqueous sodium bicarbonate, saturated aqueous NaCl, dry over MgSO4, filter and evaporate. Use the combined solid without further purification (8.0 g, 73%). 1H NMR (DMSO) delta 8.33 (d, IH, J = 7.3 Hz), 7.79 (d, IH, J = 2.0 Hz), 7.72 (s, IH), 7.07 (dd, IH, J = 7.3 and 2.0 Hz). |
50% | With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20℃; for 6h; | Synthesis of 7-Chloro-3-iodoimidazo [1 ,2-a]pyridine (compound 65-4)[0000230] To a solution of compound 65-3 (450 mg, 2.9 mmol, 1 equiv) in dimethyl formamide (4.5 mL) was added Niodosuccinimide (700 mg, 3.1 mmol, 1.05 equiv) . The reaction was stirred at room temperature for 6 hours followed by the addition of water (20 ml) and ethyl acetate (20 ml) . The layers were separated and the aqueous phase was extracted with ethyl acetate (3 x 5 ml) . The organic layers were combined, dried over sodium sulfate, filtered and concentrated under reduced pressure to a black residue. The residue from 2 runs was chromatographed on an AnaLogix 8g column using a gradient of 0-70% ethyl acetate in heptanes. The product containing fractions were combined and washed with saturated sodium thiosulfate solution (2 x 20 ml) to remove the remaining iodine color. The fractions were concentrated to give compound 65-4 as a white solid (829 mg, 50% yield) |
38% | With N-iodo-succinimide; In acetonitrile; at 20℃; for 3h; | (2b) 7-Chloro-3-iodoimidazo[1,2-a]pyridine Into acetonitrile (40 mL), <strong>[4532-25-6]7-chloroimidazo[1,2-a]pyridine</strong> (635 mg, 4.16 mmol) produced in Example 2 (2a) was dissolved, to which N-iodosuccinimide (936 mg, 4.16 mmol) was added, followed by stirring at room temperature for three hours. A solid precipitated, which was collected by filtration and purified by basic silica gel column chromatography (dichloromethane : ethyl acetate = 4 : 1, V/V) to give the desired title compound (436 mg, yield 38%). 1H-NMR (CDCl3) 5: 6.92 (1H, dd, J = 7.3, 1.8 Hz), 7.63 (1H, d, J = 1.8 Hz), 7.69 (1H, s), 8.06 (1H, d, J = 7.3 Hz). |
With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20℃; | Procedure A2 - General iodination; To a solution of 7-Chloro-imidazo[1 ,2-a]pyridine (30.9 g, 186 mmol, 1.0 equiv) in DMF (280ml) was added N-iodosuccinimide (43.6 g, 194 mmol, 1.05 equiv) and the resulting mixture was stirred overnight at RT. The thin brown slurry was diluted with water (840ml), brine (280ml) and extracted with EtOAc (560 ml). The aqueous layer was further extracted with EtOAc (3 x 280ml). The combined organic phases were washed with water (2 x 280ml), 10%w/v sodium thiosulfate (280 ml), brine (280 ml), dried (MgSO4), filtered and concentrated in vacuo to give a brown residue. The residue was triturated with ether (200ml), filtered and the solid was washed with ether (2 x 50ml) and dried on the filter to give 39 g of product. | |
With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20℃; | To a solution of 7-Chloro-imidazo[1 ,2-a]pyridine (30.9 g, 186 mmol, 1.0 equiv) in DMF (280ml) was added N-iodosuccinimide (43.6 g, 194 mmol, 1.05 equiv) and the resulting mixture was stirred overnight at RT. The thin brown slurry was diluted with water (840ml), brine (280ml) and extracted with EtOAc (560 ml). The aqueous was further extracted with EtOAc (3 x 280ml). The combined organic phases were washed with water (2 x 280ml), 10%w/v sodium thiosulfate (280 ml), brine (280 ml), dried (MgSO4) and concentrated in vacuo to give a brown residue. The residue was triturated with ether (200ml), filtered and the solid was washed ether (2 x 50ml) and dried on the filter to give 39 g of product. MS: [M+H]+ 279 | |
1.58 g | With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20℃; for 16h; | To a solution of 7-chloroimidazo[l,2-a]pyridine (7.78 mmol, 1.0 eq) in DMF (12 mL) at rt was added N-iodosuccinimide (1.84 g, 8.17 mmol, 1.05 eq). After 16 h, the brown slurry was diluted with H2O (100 mL) and Brine (15 mL). The mixture was extracted with EtOAc (100 mL). The aqueous layer was re-extracted with EtOAc (100 mL) and the collected organic layers were washed with H2O (2 x 20 mL), 10% sodium thiosulfate (20 mL), Brine (20 mL) and dried (MgSC ). After filtration, the solution was concentrated. The residue was triturated with diethyl ether (15 mL) and filtered to afford an off-white solid (1.58 g, 73% yield over 2 steps). (0246) LCMS: RT = 0.265 min, >98% 215 and 254 nM, m/z = 279.0 [M + H]+. |
With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20℃; | To a solution of 7-Chloro-imidazo[1 ,2-a]pyridine (30.9 g, 186 mmol, 1.0 equiv) in DMF (280ml) was added N-iodosuccinimide (43.6 g, 194 mmol, 1.05 equiv) and the resulting mixture was stirred overnight at RT. The thin brown slurry was diluted with water (840ml), brine (280ml) and extracted with EtOAc (560 ml). The aqueous layer was further extracted with EtOAc (3 x 280ml). The combined organic phases were washed with water (2 x 280ml), 10%w/v sodium thiosulfate (280 ml), brine (280 ml), dried (MgSO4), filtered and concentrated in vacuo to give a brown residue. The residue was triturated with ether (200ml), filtered and the solid was washed with ether (2 x 50ml) and dried on the filter to give 39 g of product. MS: [M+H]+ = 279. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 80℃; | Procedure E; To a solution of 7-Chloro-imidazo[1 ,2-a]pyridine (1.0g, 6.58mmol) in anhydrous dioxane (60ml) was added morpholine (0.64ml, 6.58mmol), NaO'Bu (1.9g, 19.74mmol) [reaction degassed by bubbling N2 through] followed by BINAP (0.43g, 0.69mmol) and Pd2dba3 (tris- (dibenzylideneacetone)dipalladium(O)) (0.32g, 0.36mmol). The mixture was heated at 80 0C overnight, then diluted with water and extracted with EtOAc. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The crude <n="102"/>residue was purified by silica chromatography to give the desired product (0.55g) MS: [M+H]+ 204. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With sodium hydrogencarbonate; In ethanol; water; at 20℃; for 20h;Reflux; | Synthesis of 7-Chloroimidazo[1 , 2-a]pyridine (compound 65-3)[0000229] To a suspension of compound 65-2 (HC1) in ethanol (15 mL) was added sodium bicarbonate powder (3.3g, 38.4 mmol, 4 equiv) and a 50% solution of chloroacetaldehyde in water (2.26 g, 14.4 mmol, 1.5 equiv) . The reaction was heated at reflux for 4 hours and stirred at room temperature for 16 hours. The reaction was concentrated under reduced pressure and the residue was dissolved in water (10 mL) and ethyl acetate (10 mL) . The layers were separated and the aqueous phase was extracted with ethyl acetate (2 x 5 mL) . The organic layers were combined, dried over sodium sulfate, filtered and concentrated to give compound 65-3 as a dark yellow oil (980 mg, 89% yield) |
85% | In ethanol; water; for 2h;Reflux; | (2a) 7-Chloroimidazo[1,2-a]pyridine Into ethanol (50 mL), 2-amino-4-chloropyridine (643 mg, 5.00 mmol) was dissolved, to which a 40% aqueous solution of chloroacetaldehyde (8.25 mL, 50 mmol) was added, followed by heating under reflux for two hours. The resulting mixture was left to cool, and the solvent was distilled off under reduced pressure. The residue thus obtained was purified by basic silica gel column chromatography (dichloromethane) to give the desired title compound (645 mg, yield 85%). 1H-NMR (CDCl3) delta: 6.79 (1H, dd, J = 7.4, 2.3 Hz), 7.57 (1H, s), 7.63 (2H, br s), 8.05 (1H, d, J = 7.4 Hz). |
79% | In water; butan-1-ol; at 130℃; for 12h; | General procedure: 2-aminopyridine (15 g, 0.159 M) was dissolved in 1-butanol (64 mL) in a 250 mL round bottom flask affixed with a magnetic stir bar. 2-chloroacetaldehyde 50% solution in water (24.3 mL, 0.191 M) was added hitherto and the reaction was heated to 130 C for 12 h.The reaction solvent was condensed in vacuo and the crude product was adsorbed onto silica. The product was purified via flash chromatography utilizing a DCM/MeOH gradient and isolated as a light, yellow oil (17 g, 90%). |
With sodium hydrogencarbonate; In ethanol; for 6h;Heating / reflux; | General Route A; Procedure A1 - General im idazopyridine ring formation; To a solution of 4-Chloro-pyridin-2-ylamine (12.8 g, 100 mmol, 1.0 equiv) in EtOH (170 ml) was added NaHCO3 (16.8 g, 200 mmol, 2.0 equiv) followed by chloroacetaldehyde (19.0 ml, 150 <n="95"/>mmol, 1.5 equiv). The mixture was refluxed for 6 h. Solvents removed under reduced pressure and the crude mixture was partitioned between water and EtOAc. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The product was purified by column chromatography (SiO2, eluted with 50% EtOAC-petrol) to afford 13.2 g of product. | |
With sodium hydrogencarbonate; In ethanol; for 6h;Heating / reflux; | To a solution of 4-Chloro-pyridin-2-ylamine (12.8 g, 100 mmol, 1.0 equiv) in EtOH (170 ml) was added NaHCO3 (16.8 g, 200 mmol, 2.0 equiv) followed by chloroacetaldehyde (19.0 ml, 150 mmol, 1.5 equiv). The mixture was refluxed <n="112"/>for 6 h. Solvents removed under reduced pressure and the crude mixture was partitioned between water and EtOAc. The organic layer was washed with brine, dried (MgSO4) and concentrated under reduced pressure. The product was purified by column chromatography (SiO2, eluted with 50% EtOAC-petrol) to afford 13.2 g of product. MS: [M+H]+ 153 | |
With sodium hydrogencarbonate; In ethanol; for 17h;Heating / reflux; | 4-Chloro-pyridin-2-ylamine (1 eq, 38.9 mmol, 5 g) is added to a solution of chloroacetic aldehyde (3 eq, 117 mmol, 15.1 ml) in EtOH (60 ml). NaHCO3 (2 eq, 77.8 mmol, 6.53 g) is added and the reaction mixture is heated at reflux for 17 h. The solvent is removed in vacuo and the product is purified by flash column chromatography eluting with 8:2 DCM/MeOH to afford 7-chloro-imidazo- [1,2-a]- pyridine as a red solid; [M+H]+ = 153 | |
With sodium hydrogencarbonate; In ethanol; water; for 10h;Reflux; | To a mixture of 4-chloropyridin-2-amine (1.0 g, 7.78 mmol, 1.0 eq) and NaHCCb (1.31 g, 15.56 mmol, 2.0 eq) in EtOH (18 mL) was added chloroacetaldehyde, 50% wt in water, (1.48 mL, 11.67 mmol, 1.5 eq). The reaction mixture was heated to reflux. After 10 h, the solvent was removed under reduced pressure and the residue was partitioned between EtOAc: H20 (1 : 1, 100 mL). The organic layer was washed with Brine (50 mL), dried (MgS04), filtered and concentrated. The material was taken through without further purification. (0243) LCMS: RT = 0.123 min, >98% 215 and 254 nM, m/z = 153.0 [M + H]+. | |
With sodium hydrogencarbonate; In ethanol; for 6h;Reflux; | To a solution of 4-Chloro-pyridin-2-ylamine (12.8 g, 100 mmol, 1.0 equiv) in EtOH (170 ml) was added NaHCO3 (16.8 g, 200 mmol, 2.0 equiv) followed by chloroacetaldehyde (19.0 ml, 150 mmol, 1.5 equiv). The mixture was refluxed for 6 h. Solvents removed under reduced pressure and the crude mixture was partitioned between water and EtOAc. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The product was purified by column chromatography (SiO2, eluted with 50% EtOAC-petrol) to afford 13.2 g of product. MS: [M+H]+ = 153. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-Bromosuccinimide; In N,N-dimethyl-formamide; for 1h; | 7-Chloro-imidazo-[1,2-a]-pyridine (1 eq, 38.9 mmol, 5.93 g) is dissolved in DMF (20 ml) at 0C and NBS (1.1 eq, 42.8 mmol, 7.61 g) is added. The reaction mixture is stirred for Ih at 0C and is diluted with EtOAc. The reaction mixture is washed with NaHCO3 and brine, dried over MgStheta4, filtered and evaporated. The product is purified by flash column chromatography eluting with 8:2 DCM/MeOH to afford 3- bromo-<strong>[4532-25-6]7-chloro-imidazo-[1,2-a]-pyridine</strong> as a brown solid; [M+H]+ = 232 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30% | With caesium carbonate; triphenylphosphine;palladium diacetate; In N,N-dimethyl-formamide; at 100℃; for 3h;Inert atmosphere; | <strong>[4532-25-6]7-chloroimidazo[1,2-a]pyridine</strong> (CAS:4532-25-6) (837.7 mg, 5.5 mmol), intermediate of example A1.m (1.5 g, 4.22 mmol), triphenylphosphine (132 mg, 0.5 mmol), cesium carbonate (1.63 g, 5 mmol) and palladium (II) acetate (56.1 mg, 0.25 mmol) were solubilised in dry DMF. The mixture was degassed 5 times using vacuum/nitrogen cycle. Then, it was heated at 100 C. for 2 hours. Additional <strong>[4532-25-6]7-chloroimidazo[1,2-a]pyridine</strong> (194 mg, 1.27 mmol) was added and the reaction was heated at 100 C. for another hour. The reaction mixture was poured onto ice-water. The aqueous layer was extracted with AcOEt. The organic layer was filtered through a pad of celite, then washed twice with saturated aqueous NaCl solution and water, dried over MgSO4, filtered and concentrated to afford a residue (2.55 g) which was purified by Normal phase on (Irregular SiOH 20-45 mum 450 g MATREX). Mobile phase (0.5% NH4OH, 95% DCM, 5% MeOH). The pure fractions were collected and the solvent was evaporated, yielding 545 mg (30%) of intermediate shown (MP=231 C., koefler). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; at 130℃; for 1h;Inert atmosphere; Microwave irradiation; | General procedure: <strong>[4532-25-6]7-chloroimidazo[1,2-a]pyridine</strong> (5) (300 mg, 1.97 mmol) was dissolved in 8:1 DMF:H2O (13.1 mL) in a microwave vial affixed with a magnetic stir bar. Thiophen-2-ylboronic acid was added followed by sodium carbonate (834 mg, 7.86 mmol). The reaction mixture was degassed with argon. Pd2(dba)3 (36 mg, 0.039 mmol) and P(Cy)3 (33 mg, 0.118 mmol) was added to the reaction mixture and the vial was sealed. The reaction was heated by microwave irradiation to 130 C for 1 h. After, the reaction mixture was diluted with ethyl acetate and washed three times with saturated sodium bicarbonate and three times with deionized water. The organic layer was dried over anhydrous sodium sulfate and the solvent was removed in vacuo. The crude product was absorbed onto silica. The product was purified via flash chromatography utilizing a DCM/MeOH gradient and isolated as a brown solid (223 mg, 59%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; at 130℃; for 1h;Inert atmosphere; Microwave irradiation; | General procedure: <strong>[4532-25-6]7-chloroimidazo[1,2-a]pyridine</strong> (5) (300 mg, 1.97 mmol) was dissolved in 8:1 DMF:H2O (13.1 mL) in a microwave vial affixed with a magnetic stir bar. Thiophen-2-ylboronic acid was added followed by sodium carbonate (834 mg, 7.86 mmol). The reaction mixture was degassed with argon. Pd2(dba)3 (36 mg, 0.039 mmol) and P(Cy)3 (33 mg, 0.118 mmol) was added to the reaction mixture and the vial was sealed. The reaction was heated by microwave irradiation to 130 C for 1 h. After, the reaction mixture was diluted with ethyl acetate and washed three times with saturated sodium bicarbonate and three times with deionized water. The organic layer was dried over anhydrous sodium sulfate and the solvent was removed in vacuo. The crude product was absorbed onto silica. The product was purified via flash chromatography utilizing a DCM/MeOH gradient and isolated as a brown solid (223 mg, 59%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; at 130℃; for 1h;Inert atmosphere; Microwave irradiation; | General procedure: <strong>[4532-25-6]7-chloroimidazo[1,2-a]pyridine</strong> (5) (300 mg, 1.97 mmol) was dissolved in 8:1 DMF:H2O (13.1 mL) in a microwave vial affixed with a magnetic stir bar. Thiophen-2-ylboronic acid was added followed by sodium carbonate (834 mg, 7.86 mmol). The reaction mixture was degassed with argon. Pd2(dba)3 (36 mg, 0.039 mmol) and P(Cy)3 (33 mg, 0.118 mmol) was added to the reaction mixture and the vial was sealed. The reaction was heated by microwave irradiation to 130 C for 1 h. After, the reaction mixture was diluted with ethyl acetate and washed three times with saturated sodium bicarbonate and three times with deionized water. The organic layer was dried over anhydrous sodium sulfate and the solvent was removed in vacuo. The crude product was absorbed onto silica. The product was purified via flash chromatography utilizing a DCM/MeOH gradient and isolated as a brown solid (223 mg, 59%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | With tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; at 130℃; for 1h;Inert atmosphere; Microwave irradiation; | <strong>[4532-25-6]7-chloroimidazo[1,2-a]pyridine</strong> (5) (300 mg, 1.97 mmol) was dissolved in 8:1 DMF:H2O (13.1 mL) in a microwave vial affixed with a magnetic stir bar. Thiophen-2-ylboronic acid was added followed by sodium carbonate (834 mg, 7.86 mmol). The reaction mixture was degassed with argon. Pd2(dba)3 (36 mg, 0.039 mmol) and P(Cy)3 (33 mg, 0.118 mmol) was added to the reaction mixture and the vial was sealed. The reaction was heated by microwave irradiation to 130 C for 1 h. After, the reaction mixture was diluted with ethyl acetate and washed three times with saturated sodium bicarbonate and three times with deionized water. The organic layer was dried over anhydrous sodium sulfate and the solvent was removed in vacuo. The crude product was absorbed onto silica. The product was purified via flash chromatography utilizing a DCM/MeOH gradient and isolated as a brown solid (223 mg, 59%). 1H NMR (400 MHz, Chloroform-d) delta 8.07 (dd, J = 7.0, 2.7 Hz, 1H), 7.81 (s, 1H), 7.63 (s, 1H), 7.54 (s, 1H), 7.38 (s, 1H), 7.35-7.30 (m, 1H), 7.14-7.07 (m, 1H), 7.03 (d, J = 5.4 Hz, 1H). 13C NMR (100 MHz, Chloroform-d) delta 145.57, 142.02, 134.43, 130.87, 128.29, 125.88, 125.59, 124.20, 112.82, 112.33, 111.40. ESIMS m/z [M+H]+ 201. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; water; at 140℃; for 24h; | In a 10 ml flask,Add the magnet,7-Chloroimidazo [1,2-a] pyridine (0.3 mmol) was added,2-chlorobenzaldehyde (0.9 mmol),Potassium carbonate (0.9 mmol),Tetrabutylammonium bromide (0.9 mmol),Palladium acetate (5 mol%),4,5-bis (diphenylphosphino) -9,9-dimethylXanthene (10mol%),N, N-dimethylacetamide (4 mL),Water (0.1 mL).The reaction mixture was reacted in a 140 oil bath for 24 hours,Cooled to room temperature,An appropriate amount of water was added and extracted three times with ethyl acetate,Combine organic phase,Dried over anhydrous magnesium sulfate,Concentrated by filtration, concentrated column chromatography,The product was isolated 47 mg,Yield 62%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; zinc; In acetonitrile; at 80℃; for 4h;Inert atmosphere; Sealed tube; | General procedure: Under argon protection, NiCl2·6H2O (0.05mmo 1,11.9mg), dppf (0.06mmol, 33.3mg), Zetan (0·2mmol, 13.0mg), DMAP (1.0mmol, 122.2mg), Zetan(CN)2 (0.8mmol) , 93.9mg),p-Chloroanisole (1.0 mmol, 140.6 mg) and acetonitrile (5.0 mL) were sequentially added in a 25.0 mL sealed tube, then directly put it into the oil bath at 60 C, and heating was stopped after 6h, and cooled to room temperature, the reaction solution was directly filtered through a short silica gel column, washed with dichloromethane, concentrated and purified by silica gel column chromatography( given that the product is most easily pulled out, in order to avoid loss of sample mix, unless otherwise noted, both are wet method). Eluent: petroleum ether / ethyl acetate = 20:1, the product was 117.2 mg as a white solid, yield 88%, and 1H NMR purity was greater than 98%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With tri-tert-butyl phosphine; palladium diacetate; potassium carbonate; In toluene; for 24h;Reflux; | 50 g (327.69 mmol) of compound [2-1] were added to the reaction flask.53.1 g (393.23 mmol) of 1- (2-aminophenyl) ethanone,1.4 g (6.55 mmol) palladium (II) acetate,Potassium carbonate 67.9 g (491.53 mmol),6.3 mL (13.1 mmol) of 50% tri-t-butylphosphine, Stirring reflux with 600 mL of toluene for 24 hours.After completion of the reaction, saturated aqueous ammonium solution was poured into the reaction solution and extracted with ethyl acetate. The organic layer is separated, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by column chromatography to prepare 55.1 g (67%) of an intermediate compound [2-1] as a yellow solid. |
Tags: 4532-25-6 synthesis path| 4532-25-6 SDS| 4532-25-6 COA| 4532-25-6 purity| 4532-25-6 application| 4532-25-6 NMR| 4532-25-6 COA| 4532-25-6 structure
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