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[ CAS No. 10400-19-8 ] {[proInfo.proName]}

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Chemical Structure| 10400-19-8
Chemical Structure| 10400-19-8
Structure of 10400-19-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 10400-19-8 ]

CAS No. :10400-19-8 MDL No. :MFCD00464814
Formula : C6H4ClNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :141.56 Pubchem ID :-
Synonyms :

Safety of [ 10400-19-8 ]

Signal Word:Danger Class:8
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501 UN#:3265
Hazard Statements:H302-H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 10400-19-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 10400-19-8 ]
  • Downstream synthetic route of [ 10400-19-8 ]

[ 10400-19-8 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 10400-19-8 ]
  • [ 20826-04-4 ]
YieldReaction ConditionsOperation in experiment
94% at 0 - 155℃; for 10 h; Thionyl chloride (96.74 g, 58.9 [ML,] 0. [813] mol) was added to 3-pyridinecarboxylic acid (also named nicotinic acid) (20 [G,] 0.163 mol) and heated at reflux [(-80 C)] for 3 h. The thionyl chloride was then distilled off under reduced pressure. The resulting acid chloride was cooled to 0 [TO-5 C,] and bromine (13 mL, 0.163 mol) was added. The reaction mixture was heated at [155 C] for 8-10 h, then cooled to room temperature and quenched with ice- cold water (200 mL) added dropwise, causing a white solid to form. The solid was collected using filtration and dried to provide the title compound (31.5 g, 94percent yield).
Reference: [1] Patent: WO2004/35545, 2004, A2, . Location in patent: Page 45-46
  • 2
  • [ 10400-19-8 ]
  • [ 553-53-7 ]
Reference: [1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013, vol. 52, # 10, p. 1318 - 1324
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 19, p. 4661 - 4665
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 21, p. 9942 - 9959
[4] Patent: CN107011255, 2017, A,
[5] Medicinal Chemistry Research, 2018, vol. 27, # 3, p. 744 - 755
[6] Patent: WO2018/71740, 2018, A1, . Location in patent: Page/Page column 22; 23; 24
  • 3
  • [ 10400-19-8 ]
  • [ 29681-44-5 ]
Reference: [1] Journal of Organic Chemistry, 1984, vol. 49, # 26, p. 5237 - 5243
  • 4
  • [ 10400-19-8 ]
  • [ 71-36-3 ]
  • [ 6938-06-3 ]
Reference: [1] Green Chemistry, 2010, vol. 12, # 4, p. 650 - 655
  • 5
  • [ 10400-19-8 ]
  • [ 100-51-6 ]
  • [ 94-44-0 ]
Reference: [1] Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1937, vol. 10, p. 515,519[2] Chem. Zentralbl., 1938, vol. 109, # I, p. 3199
[3] Collection of Czechoslovak Chemical Communications, 1951, vol. 16/17, p. 344,345
  • 6
  • [ 10400-19-8 ]
  • [ 16837-38-0 ]
Reference: [1] Biochemische Zeitschrift, 1930, vol. 229, p. 164,166
  • 7
  • [ 10400-19-8 ]
  • [ 61-54-1 ]
  • [ 29876-14-0 ]
Reference: [1] Canadian Journal of Research, Section B: Chemical Sciences, 1946, vol. 24, p. 224,229
  • 8
  • [ 10400-19-8 ]
  • [ 34562-97-5 ]
Reference: [1] Patent: WO2013/8182, 2013, A1,
[2] Patent: WO2013/168019, 2013, A1,
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