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Chemical Structure| 10405-07-9 Chemical Structure| 10405-07-9

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Chemical Structure| 10405-07-9

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Product Details of [ 10405-07-9 ]

CAS No. :10405-07-9
Formula : C4H11NO2
M.W : 105.14
SMILES Code : OC[C@@H](N)CCO
MDL No. :MFCD09863824

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Application In Synthesis of [ 10405-07-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10405-07-9 ]

[ 10405-07-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10405-07-9 ]
  • [ 24424-99-5 ]
  • [ 128427-10-1 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In tetrahydrofuran; for 0.5h; A solution of compound (S)-1 (1.57 g, 11.4 mmol) and triethylamine (1.2 g, 12 mmol) in dry THF was added dropwise to a solution of lithium aluminum hydride (1.74 g, 45.6 mmol) in 20 mL of dry THF at 0 C for 20 min, after which the reaction mixture was refluxed for 4 h. The reaction was quenched with a cold saturated NH4Cl solution (10 mL), after which a 1 M NaOH solution (5 mL) and Boc-anhydride (3.74 g, 17.1 mmol) were added to the reaction mixture and stirred for 30 min. The reaction mixture was filtered and the solvent was evaporated under reduced pressure. The residue was extracted with EtOAc (2 × 20 mL) and dried over anhydrous Na2SO4. After evaporation of the organic extract, the residue was dissolved in dry CH2Cl2 (20 mL). 2,2-Dimethoxypropane (1.38 mL, 11.4 mmol) and cat. PTSA were added and the reaction mixture was stirred at an ambient temperature for 3 h. The organic layer was evaporated under reduced pressure to afford the crude acetonide, which was purified by column chromatography on silica gel (60-120 mesh, EtOAc/hexane, 2:8) to yield 6 (1.96 g, 70%) as a colorless oil (1.96 g, 70%).
 

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