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Chemical Structure| 10473-14-0 Chemical Structure| 10473-14-0

Structure of 10473-14-0

Chemical Structure| 10473-14-0

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Product Details of [ 10473-14-0 ]

CAS No. :10473-14-0
Formula : C5H10O
M.W : 86.13
SMILES Code : CC(O)C(C)=C
MDL No. :MFCD00060892

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Application In Synthesis of [ 10473-14-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10473-14-0 ]

[ 10473-14-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 108-86-1 ]
  • [ 10473-14-0 ]
  • [ 21869-55-6 ]
  • 3
  • [ 369-57-3 ]
  • [ 10473-14-0 ]
  • [ 21869-55-6 ]
  • [ 87422-10-4 ]
  • 4
  • [ 53595-65-6 ]
  • [ 6163-58-2 ]
  • [ 10473-14-0 ]
  • 5-(2-methyl-3-oxobutyl)-thiophene-2-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
4.1% With sodium hydrogencarbonate;palladium diacetate; In 1-methyl-pyrrolidin-2-one; Preparation 10 5-(2-methyl-3-oxobutyl)-thiophene-2-sulfonamide 5-bromothiophene-2-sulfonamide (5.2 g, 21.5 mmol) and 3-methyl-3-buten-2-ol (2.8 g, 32.2 mmol) were dissolved in N-methylpyrrolidinone (40 mL) and treated with catalytic palladium diacetate (96 mg, 0.43 mmol), tris-(o-tolyl)-phosphine (262 mg, 0.86 mmol), and NaHCO3(2.2 g, 25.8 mmol). The mixture was stirred at 160C for 48 hours. TLC indicated the reaction was ca. 50% completed at that time. The solution was cooled to ambient temperature and partitioned between H2O/ethyl acetate, dried (MgSO4) and concentrated in vacuoto a dark brown oil. The residue was applied to a silica chromatography column and eluted with 2:3 hexane/ethyl acetate to yield 220 mg of a pale brown oil (4.1%).
 

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