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Structure of 10574-69-3

Chemical Structure| 10574-69-3

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Product Details of [ 10574-69-3 ]

CAS No. :10574-69-3
Formula : C10H9NOS2
M.W : 223.31
SMILES Code : S=C(N1CC2=CC=CC=C2)SCC1=O
MDL No. :MFCD00086924
InChI Key :ZFHVUMCTGGAWBM-UHFFFAOYSA-N
Pubchem ID :97673

Safety of [ 10574-69-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P264-P280-P305+P351+P338+P337+P313

Application In Synthesis of [ 10574-69-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10574-69-3 ]

[ 10574-69-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10574-69-3 ]
  • [ 174623-07-5 ]
  • (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)thiophen-2-yl)benzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% With piperidine; In ethanol; at 90℃; for 2h; To a solution of <strong>[174623-07-5]4-(5-formylthiophen-2-yl)benzoic acid</strong> (25.1, 1.0 g, 4.3 mmol) in ethanol (20 mL), 3-benzyl-2-thioxothiazolidin-4- one (25.la, 0.96 g, 4.3 mmol) and piperidine (0.36 g, 4.3 mmol) were added at room temperature. The reaction mixture was then heated at 90 C for 2 h. After completion, ethanol was removed under reduced pressure, water (30 mL) was added and pH was adjusted to 7 by addition of citric acid solution. The precipitated solid was collected by filtration and the product was purified by washings with diethyl ether and pentane to afford (Z)-4-(5-((3- benzyl-4-oxo-2-thioxothiazolidin-5 -ylidene)methyl)thiophen-2-yl)benzoic acid (25) as brown solid.Yield: 0.90 g, 50.0%. MS (ES-) m/z = 436.4 [M-1], ?H NIVIR (400 MHz, d6-DMSO) 13.12 (bs, 1H), 8.15 (s, 1H), 7.97 (dd, 4H, J = 26.7, 8.1 Hz), 7.83 (dd, 2H, J = 22.0, 3.6 Hz),7.33 (m, 5H), 5.24 (s, 2H)
 

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