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Chemical Structure| 1057720-25-8 Chemical Structure| 1057720-25-8

Structure of 1057720-25-8

Chemical Structure| 1057720-25-8

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Product Details of [ 1057720-25-8 ]

CAS No. :1057720-25-8
Formula : C11H13BrFNO2
M.W : 290.13
SMILES Code : O=C(OC(C)(C)C)NC1=C(F)C=CC=C1Br
MDL No. :MFCD24470774

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Application In Synthesis of [ 1057720-25-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1057720-25-8 ]

[ 1057720-25-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 98968-72-0 ]
  • [ 1057720-25-8 ]
YieldReaction ConditionsOperation in experiment
78% N-Boc-2-fluoroaniline (compound A-4) (100 g, 0.47 mol) was dissolved in THF to prepare a 0.5 mol / L solution 1, and 2.5 M n-BuLi n-hexane was used as the solution 2.Then, solution 1 and solution 2 were pumped into the first tee connection of the tubular reactor at a flow rate of 60 mL / min (0.03 mol / min) and 30 mL / min (0.075 mol / min), respectively, and began to mix at -15 C. After the reaction stays for 0.3min, the reaction stays at 0 C for 0.5min.1,2-Dibromoethane was pumped into the second tee connection at a flow rate of 5.2 mL / min (0.06 mol / min) to start mixing. The reaction was left at 15 C for 3 minutes and flowed out of the tube reactor.The solution was dropped into a stirred flask containing 250 g of a 27% ammonium chloride aqueous solution by mass and quenched. 500 g of ethyl acetate was added, and the aqueous layer was separated.The organic layer was washed twice with 300 g of water, then concentrated under reduced pressure at 40 C to about 100 g, 200 g of n-hexane was added, and the mixture was stirred at 0-10 C for 30 minutes and then filtered.The filter cake was washed with 60 g of n-hexane, and dried under reduced pressure to constant weight at 40 C.106 g of compound I was obtained with a yield of 78% and a purity of 98.1%.
 

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