Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 98968-72-0 | MDL No. : | MFCD04112559 |
Formula : | C11H14FNO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | AUHNQFOFWVWFTH-UHFFFAOYSA-N |
M.W : | 211.23 | Pubchem ID : | 4935500 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
![]() |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | at 20℃; for 6h;Heating / reflux; | tert-Butyl 2-fluorophenylcarbamate; To a solution of di-tert-butyldicarbonate (45.2 g, 207 mmol, 1.0 equiv) in tetrahydrofuran (210 mL) at room temperature was added 2-fluoroaniline (20.0 mL, 207 mmol). The reaction was heated to reflux and held there for 6h. It was cooled, concentrated, dissolved in pentane, washed with 5% citric acid, then 1 M potassium bisulfate (2x), then water, then 20% potassium hydroxide, then brine, dried over magnesium sulfate, and concentrated to give 48.0 g (quant) as an amber oil which was used without purification.'H-NMR (CDC13, 500 MHz) 8 1.52 (s, 9H), 6.68 (bs, 1H), 6.85-7. 20 (m, 3H), 8.07 (dd, J=8. 1,8. 1,1H). Mass spec.: 234.18 (MNa) +. |
98.9% | In tetrahydrofuran; at 25 - 80℃; for 12h; | To a solution of 2-fluoroaniline (C1.1-a) (25 g, 225 mmol, 1.0 equiv) in THF (300 mL) was added Boc2O (73.6 g, 337 mmol, 77.5 mL, 1.5 equiv) at 25C, and then stirred at 80C for 12h. The reaction mixture was concentrated under reduced pressure to give tert-butyl N-(2- fluorophenyl) carbamate (C1.1-b) (47 g, 223 mmol, 98.90% yield) as colorless oil. 1H NMR (DMSO-d6, 400MHz) δ8.98 (s, 1H), 7.68-7.60 (m, 1H), 7.27-7.10 (m, 3H), 1.50 (s, 9H) |
98.90% | In tetrahydrofuran; at 25 - 80℃; for 12h; | To a solution of 2-fluoroaniline (1.1-a) (25 g, 225 mmol, 1.0 equiv) in THF (300 mL) was added Boc2O (73.6 g, 337 mmol, 77.5 mL, 1.5 equiv) at 25C, and then stirred at 80C for 12 h. The reaction mixture was concentrated under reduced pressure to give tert-butyl N-(2-fluorophenyl) carbamate (1.1-b) (47 g, 223 mmol, 98.90% yield) as colorless oil. [1123] 1H NMR (DMSO-d6, 400MHz) δ8.98 (s, 1H), 7.68-7.60 (m, 1H), 7.27-7.10 (m, 3H), 1.50 (s, 9H) |
98.90% | In tetrahydrofuran; at 25 - 80℃; for 12h; | To a solution of 2-fluoroaniline (1.1-a) (25 g, 225 mmol, 1.0 equiv) in THF (300 mL) was added Boc2O (73.6 g, 337 mmol, 77.5 mL, 1.5 equiv) at 25C, and then stirred at 80C for 12 h. The reaction mixture was concentrated under reduced pressure to give tert-butyl N-(2-fluorophenyl) carbamate (1.1-b) (47 g, 223 mmol, 98.90% yield) as colorless oil. [1123] 1H NMR (DMSO-d6, 400MHz) δ8.98 (s, 1H), 7.68-7.60 (m, 1H), 7.27-7.10 (m, 3H), 1.50 (s, 9H) |
97.1% | In tetrahydrofuran; for 48h;Reflux; | o-fluoroaniline111g (1.0mol) and Boc anhydride 327g (1.5mol) were stirred and refluxed in 2200ml of dry tetrahydrofuran for 48h, and the end point of the reaction was identified by thin layer (developing agent: dichloromethane-n-pentane = 1:4). After room temperature, filtration, the filtrate was concentrated to dryness, and the residue was added 1500 ml of petroleum ether, stirred vigorously for 30 min, and allowed to stand, and the supernatant was decanted.The residue was concentrated to dryness to give 205 g of yd.Yield 97.1% |
96% | In tetrahydrofuran;Heating / reflux; | To a solution of di-tert-butyldicarbonate (90.4 g, 414 mmol) in tetrahydrofuran (414 mL) was added 2-fluorobenzenamine (40.0 mL, 414 mmol). The reaction was heated at reflux overnight. The reaction was cooled, concentrated, dissolved in pentane, washed, in order, with 1 N potassium bisulfate (2×), water, 20% potassium hydroxide, and brine, and then dried over magnesium sulfate and concentrated to give a light brown oil which was dried under high vacuum to give 83.7 g (96%) as a light brown oil which was used without further purification. 1H-NMR (CDCl3, 500 MHz) δ 1.52 (s, 9H), 6.68 (bs, 1H), 6.85-7.20 (m, 3H), 8.07 (dd, J=8.1, 8.1 Hz, 1H). Mass spec.: 234.18 (MNa)+. |
In tetrahydrofuran; n-Pentane; | tert-Butyl 2-fluorophenylcarbamate To a solution of di-tert-butyldicarbonate (45.2 g, 207 mmol, 1.0 equiv.) in tetrahydrofuran (210 mL) at room temperature was added 2-fluoroaniline (20.0 mL, 207 mmol). The reaction was heated to reflux and held there for 6h. It was cooled, concentrated, dissolved in pentane, washed with 5% citric acid, then 1 M potassium bisulfate (2*), then water, then 20% potassium hydroxide, then brine, dried over magnesium sulfate, and concentrated to give 48.0 g (quant.) as an amber oil which was used without purification. 1H-NMR (CDCl3, 500 MHz) δ 1.52 (s, 9H), 6.68 (bs, 1H), 6.85-7.20 (m, 3H), 8.07 (dd, J=8.1, 8.1, 1H). Mass spec.: 234.18 (MNa)+. | |
450 mg | In tetrahydrofuran; at 120℃; for 6h;Microwave irradiation; | Aniline 7: Step i: To a solution of 2-fluoroaniline (333 mg, 3.0 mmol) in THF (Volume: 2 ml) was added di-tert-butyl dicarbonate (655 mg, 3.0 ml). The mixture was heated to 120 C under microwave irradiation for 6 hours, cooled and concentrated. The crude product was purified by ISCO affording desired product as an oil (450 mg). |
To a solution of 2-fluoroaniline (1.0 eq.) in tetrahydrofuran (0.2 M) at 0 C. under N2 atmosphere was added dropwise 1M NaHMDS (2.5 eq.). The reaction was stirred for 15 minutes at 0 C., and a solution of di-tert-butyl dicarbonate in tetrahydrofuran was added. The reaction was warmed to room temperature overnight. The solvent was evaporated, and the resulting residue was quenched with 0.1N HCl aqueous solution. The aqueous suspension was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous MgSO4, and concentrated en vacuo. The crude material was purified by flash chromatography on a COMBIFLASH system (ISCO) using 0-5% ethyl acetate in hexane to give product as light yellow oil. | ||
To a solution of 2-fluoroaniline ( 1.0 eq ) in tetrahydrofuran (0.2 M) at O0C under N2 atmosphere was added dropwise IM NaHMDS (2.5 eq.) The reaction was stirred for 15 minutes at O0C, and a solution of di-teτt-butyl dicarbonate in tetrahydrofuran was added. The reaction was warmed to room temperature overnight. The solvent was evaporated, and the resulting residue was quenched with 0.1N HCl aqueous solution. The aqueous suspension was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous MgSO4, and concentrated en vacuo. The crude material was purified by flash chromatography on a COMBIFLASH system (ISCO) using 0-5% ethyl acetate in hexane to give product as light <n="171"/>yellow oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | tert-Butyl 2-fluorophenylcarbamate (42.7 g, 202 mmol) was concentrated from toluene in vacuo (3×) to remove any traces of water. The resulting residue was dissolved in tetrahydrofuran (600 mL), and cooled to -78 C. To this was added tert-butyllithium (1.7 M in pentane, 285 mL, 485 mmol) in dropwise fashion. After addition was complete, the reaction was stirred at -78 C. for 30 minutes. The solution was allowed to gradually warm to -20 C. before re-cooling to -78 C. To this was added dimethylformamide (46.9 mL, 606 mmol). The reaction was allowed to gradually warm to room temperature overnight. The reaction was poured into a separatory funnel containing diethyl ether and water. The organics were washed with water (3×) and concentrated. The combined aqueous washes were neutralized with 1 M potassium bisulfate and extracted with diethyl ether. The ethereal layers were combined with the other organics, washed with water, then brine, dried over magnesium sulfate, and concentrated to give 48.1 g (100%) as a yellow oil which was used without further purification. 1H-NMR (CDCl3, 500 MHz) δ 1.50 (s, 9H), 7.27 (m, 1H), 7.35 (m, 1H), 7.56 (d, J=7.6 Hz, 1H), 7.85 (bs, 1H), 9.99 (d, J=1.2 Hz, 1H). Mass spec.: 262.16 (MNa)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | Step A: (2-fluoro-6-iodo-phenyl)-carbamic acid terf-butyl esterTo a cooled (-78 C) solution of (2-fluoro-phenyl)-carbamic acid ferf-butyl ester (38.0 g, 180 mmol) in THF (700 mL) under nitrogen was added ferf-butyllithium (1.7 M, 240 mL, 408 mmol). The mixture was stirred for 1 h at -78 C and then a solution of iodine (60.8 g, 240 mmol) in THF (150 mL) was added slowly. The reaction mixture was stirred for further 1 h. Saturated aqueous ammonium chloride (100 mL) was added slowly and the mixture was warmed to RT. The layers were separated and the aqueous layer was extracted with ethyl acetate (2 x 100 mL). The combined organic fractions were washed with brine (200 mL), dried over anhydrous sodium sulfate, and concentrated. The residue was purified by flash chromatography (5% ethyl acetate:hexanes) to afford 39.1 g (65%) of the title compound as a while solid. 1 H NMR (300 MHz, CDCI3): δ 1 .50 (s, 9H), 5.98 (br. s, 1 H), 6.92 - 6.99 (m, 1 H), 7.08 - 7.15 (m, 1 H), 7.62 (dt, J=7.8, 1.2 Hz, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | A solution of te/t-butyllithium in pentane (1.7M, 34ml, 58mmol) was added with caution to a solution of (2-fluoro-phenyl)-carbamic acid tert-butyl ester whilst cooling to less than -50C. The mixture was maintained at this temperature, stirred for 3h then poured onto a slurry of THF and dry ice. The mixture was allowed to warm to room temperature, diluted with water and evaporated in vacuo. The residue was taken up in water and washed with diethyl ether. A solution of 0.3M potassium hydrogen sulphate was added until pH6 and extracted with chloroform. The chloroform extracts were combined, washed with brine, dried and reduced to give a white solid; yield 2.7g, 37%. | |
With carbon dioxide; tert.-butyl lithium; In tetrahydrofuran; pentane; | 2-(tert-Butoxycarbonylamino)-3-fluoro-benzoic acid To a solution of <strong>[98968-72-0]tert-butyl 2-fluorophenylcarbamate</strong> (44.0 g, 208 mmol) in tetrahydrofuran (660 mL) at -78 C. was added tert-butyllithium in pentane (1.7 M, 306 mL, 2.5 equivx) dropwise. After addition was complete, the reaction was stirred at -78 C. for 30 min. The solution was allowed to gradually reach -20 C. before being recooled to -78 C. and transferred via canula to a slurry of carbon dioxide (excess) and tetrahydrofuran (500 mL). The solution was allowed to slowly warm to room temperature. The reaction mixture was concentrated to remove most of the tetrahydrofuran, and poured into a sep funnel containing water and diethyl ether. The layers were separated, and the aqueous extracted with diethyl ether twice more. The ethereals were discarded. The aqueous was acidified with 5% citric acid, extracted with diethyl ether (3*). The ethereal was dried over magnesium sulfate, and concentrated to give a light yellow solid which was recrystallized from hot toluene to give 37.1 g (70%) as a faint yellow solid. 1H-NMR (CDCl3, 500 MHz) δ 1.50 (s, 9H), 6.25 (bs, 1H), 7.18 (ddd, J=7.9, 7.9, 4.9, 1H), 7.33 (dd, J=9.5, 9.2, 1H), 7.79 (d, J=7.9, 1H), 7.94 (s, 1H). Mass spec.: 278.21 (MNa)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; In tetrahydrofuran; hydrogenchloride; | EXAMPLE 117 Preparation of 2-fluoro-6-methylthioaniline A mixture of N-(t-butoxycarbonyl)-2-fluoroaniline (5.0 g, 24 mmoles) in anhydrous tetrahydrofuran (50 ml) was cooled to -78 C. under a nitrogen atmosphere. To this solution was added t-butyl lithium (2.0M, 57.6 mmoles, 28.8 ml) at such a rate that the temperature did not exceed -65 C. When the addition was complete, the mixture was stirred at -78 C. for an additional 15 minutes and at -20 C. for 2.5 hours. To this reaction mixture was added dimethyl disulfide (2.82 g, 30 mmoles) in 10 ml of anhydrous tetrahydrofuran while maintaining the temperature at -20 C. for an additional hour. The mixture was allowed to warm to ambient temperature and then 25 ml of 1N sodium hydroxide was added. The mixture obtained was extracted with diethyl ether (2*100 ml). The organic phase was separated and dried over magnesium sulfate and then the solvent was removed by evaporation under reduced pressure to obtain a tan solid. This was hydrolized in dilute hydrochloric acid (6N, 200 ml) by heating to reflux for three hours. The resulting solution was extracted with diethyl ether and the aqueous layer was neutralized with sodium hydroxide (6N, 200 ml), and extracted with methylene chloride, dried over magnesium sulfate and the solvent removed by evaporation under reduced pressure to obtain an amber oil. This was distilled to give 3.2 g (85% of theory) of the title compound, having a b.p. of 62-65 C. at 0.2 mm Hg. Analysis: Calculated for C7 H8 FNS: C, 58.48; H, 5.13; N, 8.91. Found: C, 53.84; H, 5.55; N, 8.73. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | N-Boc-2-fluoroaniline (compound A-4) (100 g, 0.47 mol) was dissolved in THF to prepare a 0.5 mol / L solution 1, and 2.5 M n-BuLi n-hexane was used as the solution 2.Then, solution 1 and solution 2 were pumped into the first tee connection of the tubular reactor at a flow rate of 60 mL / min (0.03 mol / min) and 30 mL / min (0.075 mol / min), respectively, and began to mix at -15 C. After the reaction stays for 0.3min, the reaction stays at 0 C for 0.5min.1,2-Dibromoethane was pumped into the second tee connection at a flow rate of 5.2 mL / min (0.06 mol / min) to start mixing. The reaction was left at 15 C for 3 minutes and flowed out of the tube reactor.The solution was dropped into a stirred flask containing 250 g of a 27% ammonium chloride aqueous solution by mass and quenched. 500 g of ethyl acetate was added, and the aqueous layer was separated.The organic layer was washed twice with 300 g of water, then concentrated under reduced pressure at 40 C to about 100 g, 200 g of n-hexane was added, and the mixture was stirred at 0-10 C for 30 minutes and then filtered.The filter cake was washed with 60 g of n-hexane, and dried under reduced pressure to constant weight at 40 C.106 g of compound I was obtained with a yield of 78% and a purity of 98.1%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of <strong>[98968-72-0]tert-butyl 2-fluorophenylcarbamate</strong> (from step 1) (1.0 eq.) in tetrahydrofuran (0.25 M) at -78C under Nz atmosphere was added dropwise 1.7 M tert- butyllithium (2.4 eq.). The reaction was warmed to -400C slowly over 2 hours, and neat trimethyl borate (3.8 eq.) was added. The reaction was warmed to room temperature over 30 minutes. An aqueous solution of IN NaOH was slowly added to the reaction and stirred for 15 minutes. The mixture was poured into ethyl acetate and acidified with 3N HCl to dissolve the solids. The aqueous layer was extracted twice with ethyl acetate, and the combined organic layers were washed with brine, dried over anhydrous MgSO4, and concentrated en vacuo. The resulting solids were stirred in 1:1 ether/hexane, filtered, and dried. The solids were carried onto the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Step 2: Boc protected 2-fluoroaniline (450mg, 2.13 mmol) was dissolved in diethylether ( Volume: 10 ml) and cooled to -78 C. t-Butyl lithium (1.7 M, 2.76 ml) was added to above solution and the reaction mixture was allowed to warm to -20 C for 3 hours. The mixture was then cooled to -78 C, and ethylbromide (1.16 g, 10.65 mmol) was added. The resulting mixture was stirred at room temperature overnight and quenched with ammonium chloride. The aqueous layer was extracted with ethyl acetate and the combined organic layer was dried and concentrated. The residue was purified by ISCO affording the product as a yellow oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of <strong>[98968-72-0]tert-butyl 2-fluorophenylcarbamate</strong> (from step 1) (1.0 eq.) in tetrahydrofuran (0.25 M) at -78 C. under N2 atmosphere was added dropwise 1.7 M tert-butyllithium (2.4 eq.). The reaction was warmed to -40 C. slowly over 2 hours, and neat trimethyl borate (3.8 eq.) was added. The reaction was warmed to room temperature over 30 minutes. An aqueous solution of 1N NaOH was slowly added to the reaction and stirred for 15 minutes. The mixture was poured into ethyl acetate and acidified with 3N HCl to dissolve the solids. The aqueous layer was extracted twice with ethyl acetate, and the combined organic layers were washed with brine, dried over anhydrous MgSO4, and concentrated en vacuo. The resulting solids were stirred in 1:1 ether/hexane, filtered, and dried. The solids were carried onto the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91.6% | With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 - 85℃; for 36h; | Intermediate II 190 g (0.90 mol), 2,4-dimethylthiophenol 125 g (0.90 mol) and DMF 2000 ml, DIPEA (N,N-diisopropylethylamine) 149 ml (0.91 mol); Stir at 80-85 C for 36 h, thin layer to identify the end of the reaction (developing agent: dichloromethane - n-pentane = 1:3), the reaction is completed, cooled to room temperature, added ethyl acetate 3000 ml and deionized water 500 ml, stirred for 20 min, and allowed to stand for separation. The organic layer was washed with saturated sodium chloride solution (300 ml × 2), dried over anhydrous sodium sulfate and filtered to remove desiccant. the filtrate was concentrated to dryness to give 273 g of colorless oil Intermediate III. yield 91.6% |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86.58% | To a mixture of <strong>[98968-72-0]tert-butyl N-(2-fluorophenyl)carbamate</strong> (C1.1-b) (10 g, 47 mmol, 1.0 equiv) in DMF (100 mL) was added NaH (2.84 g, 71 mmol, 60% purity, 1.5 equiv) slowly at 0C, the mixture was stirred 10 min at 0C, then 3-bromoprop-1-ene (8.59 g, 71 mmol, 1.5 equiv) was added, and it was stirred at 20C for 2 h. The reaction mixture was poured into H2O (100 mL), extracted with EtOAc (100 mL) for twice. The organic lawyers were washed with brine (100 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2, Petroleum ether/Ethyl acetate=1/0 to 1/0) to give compound tert-butyl N-allyl-N-(2-fluorophenyl)carbamate (C1.1-c) (10.3 g, 41 mmol, 86.58% yield) as a colorless liquid. 1H NMR (DMSO-d6,400 MHz) δ7.35-7.10 (m, 4H), 5.86-5.72 (m, 1H), 5.14-5.02 (m, 2H), 4.14 (d, J = 5.6 Hz, 2H), 1.38-1.31 (m, 9H) | |
86.58% | To a mixture of <strong>[98968-72-0]tert-butyl N-(2-fluorophenyl)carbamate</strong> (1.1-b) (10 g, 47 mmol, 1.0 equiv) in DMF (100 mL) was added NaH (2.84 g, 71 mmol, 60% purity, 1.5 equiv) slowly at 0C, the mixture was stirred 10 min at 0C, then 3-bromoprop-1-ene (8.59 g, 71 mmol, 1.5 equiv) was added, and it was stirred at 20C for 2 h. The reaction mixture was poured into H2O (100 mL), extracted with EtOAc (100 mL) for twice. The organic layers were washed with brine (100 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2, Petroleum ether/Ethyl acetate=1/0 to 9/1) to give compound tert-butyl N-allyl-N-(2-fluorophenyl)carbamate (1.1-c) (10.3 g, 41 mmol, 86.58% yield) as a colorless liquid. [1125] 1H NMR (DMSO-d6,400 MHz) δ7.35-7.10 (m, 4H), 5.86-5.72 (m, 1H), 5.14-5.02 (m, 2H), 4.14 (d, J = 5.6 Hz, 2H), 1.38-1.31 (m, 9H) | |
86.58% | To a mixture of <strong>[98968-72-0]tert-butyl N-(2-fluorophenyl)carbamate</strong> (1.1-b) (10 g, 47 mmol, 1.0 equiv) in DMF (100 mL) was added NaH (2.84 g, 71 mmol, 60% purity, 1.5 equiv) slowly at 0C, the mixture was stirred 10 min at 0C, then 3-bromoprop-1-ene (8.59 g, 71 mmol, 1.5 equiv) was added, and it was stirred at 20C for 2 h. The reaction mixture was poured into H2O (100 mL), extracted with EtOAc (100 mL) for twice. The organic layers were washed with brine (100 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2, Petroleum ether/Ethyl acetate=1/0 to 9/1) to give compound tert-butyl N-allyl-N-(2-fluorophenyl)carbamate (1.1-c) (10.3 g, 41 mmol, 86.58% yield) as a colorless liquid. [1125] 1H NMR (DMSO-d6,400 MHz) δ7.35-7.10 (m, 4H), 5.86-5.72 (m, 1H), 5.14-5.02 (m, 2H), 4.14 (d, J = 5.6 Hz, 2H), 1.38-1.31 (m, 9H) |
Tags: 98968-72-0 synthesis path| 98968-72-0 SDS| 98968-72-0 COA| 98968-72-0 purity| 98968-72-0 application| 98968-72-0 NMR| 98968-72-0 COA| 98968-72-0 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :