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Chemical Structure| 1062136-14-4 Chemical Structure| 1062136-14-4

Structure of 1062136-14-4

Chemical Structure| 1062136-14-4

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Product Details of [ 1062136-14-4 ]

CAS No. :1062136-14-4
Formula : C12H16N2O
M.W : 204.27
SMILES Code : O=C(N[C@H]1CNCCC1)C2=CC=CC=C2
MDL No. :MFCD24553221

Safety of [ 1062136-14-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1062136-14-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1062136-14-4 ]

[ 1062136-14-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 853029-57-9 ]
  • [ 1062136-14-4 ]
  • 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-benzoylaminopiperidin-1-yl)xanthine [ No CAS ]
YieldReaction ConditionsOperation in experiment
5.5 g With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 100℃; for 8h; A solution of 1 - [(4-methylquinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8-bromoxanthine 0.013 mol),(R) -N- (3-piperidinyl) benzamide (Compound I-5, 3.0 g, 0.015 mol), potassium carbonate (2.7 g, 0.021 mol) prepared as in Example 10 and N-methylpyrrolidone(NMP, 80 ml) was added to the reaction flask.Heated to 100 C for 8 hours, cooled to room temperature, and 150 g of ice water was added to the reaction mixture.Precipitate after precipitation, filter cake. The cake was dispersed in 100 ml of water and heated to 80 C for 1 hour.After falling to room temperature,The filtrate was collected to give 1 - [(4-methylquinazolin-2-yl) methyl] -3-methyl-7- (2-butyn-1-yl) -8- (3- (R) -benzoylaminopiperidin-1-yl) -oxanthine (Compound III-2).Yield: 5.5 g (73% of theory)
 

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