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Chemical Structure| 1065169-08-5 Chemical Structure| 1065169-08-5

Structure of 1065169-08-5

Chemical Structure| 1065169-08-5

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Product Details of [ 1065169-08-5 ]

CAS No. :1065169-08-5
Formula : C13H18Si
M.W : 202.37
SMILES Code : C[Si](C)(C#CC1=CC=CC(CC)=C1)C

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Application In Synthesis of [ 1065169-08-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1065169-08-5 ]

[ 1065169-08-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1065169-08-5 ]
  • [ 29074-77-9 ]
YieldReaction ConditionsOperation in experiment
100% With potassium carbonate; In methanol; at 25.0℃; for 1.0h; Step 2) 2-amino-5-[4-(difluoromethoxy)phenyl]-5-(3-ethylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one In a 100 mL round-bottomed flask was placed ((3-ethylphenyl)ethynyl)trimethylsilane (3.17 g, 15.66 mmol) and MeOH (31.3 ml) was added to give a yellow solution. Potassium carbonate (21.65 g, 157 mmol) was added and reaction stirred at 25 C. for 1 h. The reaction was partitioned between water (200 mL) and hexanes (200 mL). The organic was washed with water (100 mL) and brine (100 mL). The organic was dried over Na2SO4. The solvent was removed providing 1-ethyl-3-ethynylbenzene (2.24 g, 17.21 mmol, 110% yield) as a dark brown oil that was used as is without further purification. Using essentially the same procedure as Example 1 steps a-c the racemic 2-amino-5-[4-(difluoromethoxy)phenyl]-5-(3-ethylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one was obtained. MS m/e (M+H)+ 360.0.
 

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