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Chemical Structure| 1069473-61-5 Chemical Structure| 1069473-61-5

Structure of 1069473-61-5

Chemical Structure| 1069473-61-5

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Product Details of [ 1069473-61-5 ]

CAS No. :1069473-61-5
Formula : C8H6ClN3O2
M.W : 211.61
SMILES Code : O=C(C1=CN(C)C2=NC=NC(Cl)=C21)O
MDL No. :MFCD09909362

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1069473-61-5 ]

[ 1069473-61-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 124-38-9 ]
  • [ 1266343-30-9 ]
  • [ 1069473-61-5 ]
YieldReaction ConditionsOperation in experiment
87% STEP 2: 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid [Chem. 4]To a stirred solution of <strong>[1266343-30-9]5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine</strong> (STEP 1, 8.20 g, 33.3 mmol) in tetrahydrofuran (120 mL) was added 1.59 M n-butyllithium in hexane solution (25.1 mL, 39.9 mmol) slowly at -78 oC. After stirring at -78 oC for 1 hr, solid CO2 was added to the mixture. The resulting was warmed to room temperature gradually, and quenched with 1M HCl aqueous solution (200 mL). The mixture was extracted with dichloromethane/methanol (10/1, 200 mLx4), and the combined organic fraction was dried over magnesium sulfate. After removal of the solvent by evaporation, the residue was triturated with ethyl acetate (100 mL) and collected by filtration to give the title compound (6.11 g, 87%) as an off-white solid.;LCMS (Method A) m/z: M+1 212.0; tR = 1.30 min.
 

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