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Chemical Structure| 107188-74-9 Chemical Structure| 107188-74-9

Structure of 107188-74-9

Chemical Structure| 107188-74-9

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Product Details of [ 107188-74-9 ]

CAS No. :107188-74-9
Formula : C16H23BrN2O3
M.W : 371.27
SMILES Code : O=C(NC[C@H]1N(CC)CCC1)C2=CC(Br)=CC(OC)=C2OC
MDL No. :MFCD00894744

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Application In Synthesis of [ 107188-74-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 107188-74-9 ]

[ 107188-74-9 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 72517-23-8 ]
  • [ 22795-99-9 ]
  • [ 107188-74-9 ]
YieldReaction ConditionsOperation in experiment
87.5% Dissolve 0.486 g (1.86 mmol) of 5-bromo-2,3-dimethoxybenzoic acid in 10 ml of dry toluene, add 0.39 ml of thionyl chloride, and heat for 1 hour under the protection of argon at 60 ° C., evaporate dry,After addition of 10ml of anhydrous DCM, 0.286g of (S) -2-aminomethyl-1-ethylpyrrole was added dropwise to the ice-water bath. After the reaction was stirred at room temperature for 8 hours, it was diluted with 50ml of DCM, washed with saturated aqueous NaHCO3 Washed three times,The organic layer was dried over Na2SO4, filtered and evaporated to give a yellowish oil which was separated on a medium pressure silica gel column with mobile phase petroleum ether: ethyl acetate 2: 1. The product fractions were collected and evaporated to give 1.628 g of a slightly yellow oil 87.5percent.
 

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